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• W1201348515 endingPage "8551" @default.
• W1201348515 startingPage "8544" @default.
• W1201348515 abstract "Copper is a vital metal cofactor in enzymes that are essential to myriad biological processes. Cellular acquisition of copper is primarily accomplished through the Ctr family of plasma membrane copper transport proteins. Model peptide studies indicate that the human Ctr1 N-terminus binds to Cu(II) with high affinity through an amino terminal Cu(II), Ni(II) (ATCUN) binding site. Unlike typical ATCUN-type peptides, the Ctr1 peptide facilitates the ascorbate-dependent reduction of Cu(II) bound in its ATCUN site by virtue of an adjacent HH (bis-His) sequence in the peptide. It is likely that the Cu(I) coordination environment influences the redox behavior of Cu bound to this peptide; however, the identity and coordination geometry of the Cu(I) site has not been elucidated from previous work. Here, we show data from NMR, XAS, and structural modeling that sheds light on the identity of the Cu(I) binding site of a Ctr1 model peptide. The Cu(I) site includes the same bis-His site identified in previous work to facilitate ascorbate-dependent Cu(II) reduction. The data presented here are consistent with a rational mechanism by which Ctr1 provides coordination environments that facilitate Cu(II) reduction prior to Cu(I) transport." @default.
• W1201348515 created "2016-06-24" @default.
• W1201348515 creator A5001039339 @default.
• W1201348515 creator A5029355317 @default.
• W1201348515 creator A5037077868 @default.
• W1201348515 creator A5052912332 @default.
• W1201348515 creator A5080296967 @default.
• W1201348515 date "2015-08-10" @default.
• W1201348515 modified "2023-10-03" @default.
• W1201348515 title "Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1" @default.
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• W1201348515 doi "https://doi.org/10.1021/acs.inorgchem.5b01162" @default.
• W1201348515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26258435" @default.
• W1201348515 hasPublicationYear "2015" @default.
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