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- W120138715 endingPage "182" @default.
- W120138715 startingPage "153" @default.
- W120138715 abstract "The determination of the karyotypic changes related to mouse tumorgenesis had to await the development of banding techniques to identify normal and abnormal chromosomes and the accumulation of enough data to sort out significant from fortuitous changes. Two general approaches have been used in the study of tumors per se, particularly leukemias and the study of somatic cell hybrids in which one or both parents is a tumorigenic cell line. These experimental approaches are dealt with separately; however, same genes may control tumorigenicity in both cases. X-Rays and chemicals also induce leukemias that are associated with aneuploidy. Leukemias produced by injecting dimethylbenzanthracene (DMBA) or benzpyrene (BP) in CRW or C57BL mice resulted in a large proportion of the tumors. Evidence obtained from rats indicated that DMBA produced the same type of chromosome changes in sarcomas, leukemias, and carcinomas—that is, the agent rather than the target cell determined the type of chromosome changes. The cytogenetic analyses of mouse tumors, tumor-derived cell lines, and tumor X nontumor cell hybrids have shown that specific chromosomes play a role in the expression of tumorigenicity." @default.
- W120138715 created "2016-06-24" @default.
- W120138715 creator A5027930154 @default.
- W120138715 creator A5087307417 @default.
- W120138715 date "1983-01-01" @default.
- W120138715 modified "2023-09-26" @default.
- W120138715 title "Chromosomes and Cancer in the Mouse: Studies in Tumors, Established Cell Lines, and Cell Hybrids" @default.
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