Matches in SemOpenAlex for { <https://semopenalex.org/work/W12016373> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W12016373 endingPage "41" @default.
- W12016373 startingPage "S530" @default.
- W12016373 abstract "Fifty-two pediatric patients were diagnosed with secondary hemophagocytic lymphohistiocytosis (HLH) at the Department of Pediatrics, Siriraj Hospital between 1989 and 1998. Of these, 15 were infection-associated (IAHS), 25 were malignancy-associated (MAHS) and 12 were idiopathic HLH. Causative organisms for IAHS were Salmonella (3), Staphylococcus (2), enterobactor (2), dengue virus (3), malaria (2) and one each of Ebstein Barr virus (EBV), Serratia marcesens and Penicillium maneffei. Unlike those reported in adults and in the Western literature, 47 of 52 children in the present series were immunocompetent hosts. In addition, the proportion of MAHS was higher than expected (48.1%). Twenty-two of 25 MAHS presented with hemophagocytic syndrome and were subsequently found to have malignant diseases. Sixty per cent of MAHS (15 cases) were associated with non-Hodgkin's lymphoma (NHL), mainly T-cell. Other malignancies included acute leukemias (7) MDS (1), Langerhans cell histiocytosis (1) and histiocytic sarcoma (1). Treatment approaches were specific therapy for individuals with known causes. Supportive treatment with blood components transfusions, steroid, intravenous immunoglobulins (IVIG), and chemotherapeutic agents, mainly vinblastine and etoposides, were used in indicated cases. Of the 52 cases, 15 (28.8%) had a fatal outcome during the acute phase, and other 4 died of their subsequent malignant diseases. There was a statistically significant association between poorer prognosis and patients' age < 3 years (p= 0.004) or MAHS (p=0.005).Secondary HLH is not uncommon in Thai children who are immunocompetent. Malignancies, particulary NHL, are highly suspicious especially for cases not responsive to conventional therapy. Poor prognostic factors are age less than 3 years and MAHS." @default.
- W12016373 created "2016-06-24" @default.
- W12016373 creator A5020398386 @default.
- W12016373 creator A5054635996 @default.
- W12016373 creator A5056172369 @default.
- W12016373 creator A5057073485 @default.
- W12016373 creator A5074440136 @default.
- W12016373 date "2002-08-01" @default.
- W12016373 modified "2023-09-25" @default.
- W12016373 title "Secondary hemophagocytic lymphohistiocytosis in children: an analysis of etiology and outcome." @default.
- W12016373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12403229" @default.
- W12016373 hasPublicationYear "2002" @default.
- W12016373 type Work @default.
- W12016373 sameAs 12016373 @default.
- W12016373 citedByCount "23" @default.
- W12016373 countsByYear W120163732012 @default.
- W12016373 countsByYear W120163732013 @default.
- W12016373 countsByYear W120163732014 @default.
- W12016373 countsByYear W120163732015 @default.
- W12016373 countsByYear W120163732016 @default.
- W12016373 countsByYear W120163732017 @default.
- W12016373 countsByYear W120163732019 @default.
- W12016373 countsByYear W120163732022 @default.
- W12016373 crossrefType "journal-article" @default.
- W12016373 hasAuthorship W12016373A5020398386 @default.
- W12016373 hasAuthorship W12016373A5054635996 @default.
- W12016373 hasAuthorship W12016373A5056172369 @default.
- W12016373 hasAuthorship W12016373A5057073485 @default.
- W12016373 hasAuthorship W12016373A5074440136 @default.
- W12016373 hasConcept C126322002 @default.
- W12016373 hasConcept C187212893 @default.
- W12016373 hasConcept C203014093 @default.
- W12016373 hasConcept C2779079688 @default.
- W12016373 hasConcept C2779134260 @default.
- W12016373 hasConcept C2779338263 @default.
- W12016373 hasConcept C2779399171 @default.
- W12016373 hasConcept C71924100 @default.
- W12016373 hasConceptScore W12016373C126322002 @default.
- W12016373 hasConceptScore W12016373C187212893 @default.
- W12016373 hasConceptScore W12016373C203014093 @default.
- W12016373 hasConceptScore W12016373C2779079688 @default.
- W12016373 hasConceptScore W12016373C2779134260 @default.
- W12016373 hasConceptScore W12016373C2779338263 @default.
- W12016373 hasConceptScore W12016373C2779399171 @default.
- W12016373 hasConceptScore W12016373C71924100 @default.
- W12016373 hasLocation W120163731 @default.
- W12016373 hasOpenAccess W12016373 @default.
- W12016373 hasPrimaryLocation W120163731 @default.
- W12016373 hasRelatedWork W1988328336 @default.
- W12016373 hasRelatedWork W2096313113 @default.
- W12016373 hasRelatedWork W2314227159 @default.
- W12016373 hasRelatedWork W2316680276 @default.
- W12016373 hasRelatedWork W2595876869 @default.
- W12016373 hasRelatedWork W2793757937 @default.
- W12016373 hasRelatedWork W2894965947 @default.
- W12016373 hasRelatedWork W2921795031 @default.
- W12016373 hasRelatedWork W3041398533 @default.
- W12016373 hasRelatedWork W82548367 @default.
- W12016373 hasVolume "85 Suppl 2" @default.
- W12016373 isParatext "false" @default.
- W12016373 isRetracted "false" @default.
- W12016373 magId "12016373" @default.
- W12016373 workType "article" @default.