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- W12017329 abstract "Newly developed tools for prostaglandin synthesis are described. (1) Transition metal catalyzed reactions of strained oxygen ring systems provide useful methods for site-specific oxygenation of unsaturated carbon skeletons. Palladium(O) complexes catalyze the isomerization of α,β-epoxy ketones to β-diketones under mild conditions. The reaction pathway of the palladium(O) catalyzed reaction of 1, 3-diene 1, 2-epoxides is highly dependent on the structure and substitution pattern of the substrates; epoxides derived from flexible dienes isomerize to dienol isomers, whereas cyclic diene epoxides are transformed to β,γ-unsaturated ketones selectively. 1,3-Diene 1,4-epiperoxides give 4-hydroxy-2-alkenones or syn diepoxides depending on the nature of the catalysts. (2) New procedures for vicinal carbon group introduction to α,β-unsaturated ketones have been elaborated on the basis of stoichiometric use of organocopper reagents. (3) A highly efficient asymmetric reduction of carbonyl functions using an aluminum hydride reagent modified by axially dissymmetric binaphthol ligand has been applied to the generation of the 11R, and 15S configuration of prostaglandins. Utility of such methodologies is illustrated by the straightforward synthesis of certain prostaglandin derivatives." @default.
- W12017329 created "2016-06-24" @default.
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- W12017329 date "1981-01-01" @default.
- W12017329 modified "2023-09-23" @default.
- W12017329 title "NEW METHODOLOGIES RELATED TO PROSTAGLANDIN SYNTHESIS" @default.
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- W12017329 doi "https://doi.org/10.1016/b978-0-08-025268-1.50028-8" @default.
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