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- W1201901877 abstract "Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer. In addition, it plays a central role in survival and persistence of intracellular pathogens such as Leishmania donovani, Mycobacterium tuberculosis and Trypanosoma cruzi inside the host. The signaling mechanisms of IL-10 cytokine are not well explored and a well annotated pathway map has been lacking. To this end, we developed a pathway resource by manually annotating the IL-10 induced signaling molecules derived from literature. The reactions were categorized under molecular associations, activation/inhibition, catalysis, transport and gene regulation. In all, 37 molecules and 76 reactions were annotated. The IL-10 signaling pathway can be freely accessed through NetPath, a resource of signal transduction pathways previously developed by our group." @default.
- W1201901877 created "2016-06-24" @default.
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- W1201901877 date "2015-08-08" @default.
- W1201901877 modified "2023-10-17" @default.
- W1201901877 title "A network map of Interleukin-10 signaling pathway" @default.
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- W1201901877 doi "https://doi.org/10.1007/s12079-015-0302-x" @default.
- W1201901877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4850137" @default.
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