FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1201955184> ?p ?o ?g. }

• W1201955184 endingPage "7" @default.
• W1201955184 startingPage "7371" @default.
• W1201955184 abstract "To investigate the correlation between the exon 3 polymorphism of growth hormone receptor (GHR) gene and the responses to the recombinant human growth hormone (rhGH) therapy in children with short stature.Forty-five growth hormone deficiency (GHD) children (male: 30, female: 15, aged 10.39 ± 2.73 yrs) and twenty-five idiopathic short stature (ISS) children (male: 15, female: 10, aged 10.58 ± 2.56 yrs) admitted to our hospital were included. The polymorphism of exon 3 of GHR gene was determined using multiple PCR amplification. Treatment duration for each subject was at least 12 months. On this basis, we evaluated the correlation between treatment efficiency of rhGH therapy and GHR exon 3 polymorphism, GHD, and treatment duration.Significant difference was noted in the growth velocity (GV) of GHD children with a genotype of GHRfl compared with those with a genotype of GHRd3 (9.44 ± 2.35 vs. 11.36 ± 2.49, P < 0.05). Meanwhile, the GV of ISS patients with a genotype of GHRfl were remarkably decreased compared with those with a genotype of GHRd3 (8.74 ± 2.36 vs. 11.18 ± 2.44, P < 0.05). For the children with peak GH response of less than 5 ng/ml, statistical difference was noted in the GV of children with a genotype of GHRfl compared with those with a genotype of GHRd3 (9.55 ± 2.76 vs. 10.84 ± 1.53, P < 0.05). For the patients with peak GH response to clonidine or pyridostigmine bromide of > 5 ng/ml, a satisfactory response to rhGH therapy was noted in children with a genotype of GHRd3 compared with those of GHRfl (P < 0.05).GHRd3 was correlated with the response to rhGH therapy in children with short stature. For the patients with the same genotype, GHD caused no obvious effects on the final height. However, for the patients with peak GH response of > 5 ng/ml, a satisfactory response to rhGH therapy was noted in children with a genotype of GHRd3 compared with those of GHRfl (P < 0.05). A higher treatment efficiency was obtained in those received rhGH at an early age." @default.
• W1201955184 created "2016-06-24" @default.
• W1201955184 creator A5008450445 @default.
• W1201955184 creator A5055321638 @default.
• W1201955184 creator A5075914610 @default.
• W1201955184 creator A5081262873 @default.
• W1201955184 creator A5091518069 @default.
• W1201955184 date "2015-01-01" @default.
• W1201955184 modified "2023-09-24" @default.
• W1201955184 title "Correlation between exon 3 polymorphism of growth hormone receptor gene and the responses to rhGH therapy." @default.
• W1201955184 cites W1589806936 @default.
• W1201955184 cites W173883128 @default.
• W1201955184 cites W1988236032 @default.
• W1201955184 cites W1988951741 @default.
• W1201955184 cites W1997522702 @default.
• W1201955184 cites W2000453807 @default.
• W1201955184 cites W2006622237 @default.
• W1201955184 cites W2008257976 @default.
• W1201955184 cites W2022234447 @default.
• W1201955184 cites W2037053329 @default.
• W1201955184 cites W2047660215 @default.
• W1201955184 cites W2050853712 @default.
• W1201955184 cites W2061609074 @default.
• W1201955184 cites W2063460947 @default.
• W1201955184 cites W2074462428 @default.
• W1201955184 cites W2075598023 @default.
• W1201955184 cites W2077122859 @default.
• W1201955184 cites W2092437895 @default.
• W1201955184 cites W2099874287 @default.
• W1201955184 cites W2099960636 @default.
• W1201955184 cites W2139485422 @default.
• W1201955184 cites W2159927894 @default.
• W1201955184 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4525972" @default.
• W1201955184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26261638" @default.
• W1201955184 hasPublicationYear "2015" @default.
• W1201955184 type Work @default.
• W1201955184 sameAs 1201955184 @default.
• W1201955184 citedByCount "1" @default.
• W1201955184 countsByYear W12019551842018 @default.
• W1201955184 crossrefType "journal-article" @default.
• W1201955184 hasAuthorship W1201955184A5008450445 @default.
• W1201955184 hasAuthorship W1201955184A5055321638 @default.
• W1201955184 hasAuthorship W1201955184A5075914610 @default.
• W1201955184 hasAuthorship W1201955184A5081262873 @default.
• W1201955184 hasAuthorship W1201955184A5091518069 @default.
• W1201955184 hasConcept C104317684 @default.
• W1201955184 hasConcept C113675107 @default.
• W1201955184 hasConcept C126322002 @default.
• W1201955184 hasConcept C134018914 @default.
• W1201955184 hasConcept C135763542 @default.
• W1201955184 hasConcept C149737253 @default.
• W1201955184 hasConcept C2777871287 @default.
• W1201955184 hasConcept C2778754045 @default.
• W1201955184 hasConcept C2779952775 @default.
• W1201955184 hasConcept C2984496839 @default.
• W1201955184 hasConcept C36823959 @default.
• W1201955184 hasConcept C54355233 @default.
• W1201955184 hasConcept C71315377 @default.
• W1201955184 hasConcept C71924100 @default.
• W1201955184 hasConcept C86803240 @default.
• W1201955184 hasConceptScore W1201955184C104317684 @default.
• W1201955184 hasConceptScore W1201955184C113675107 @default.
• W1201955184 hasConceptScore W1201955184C126322002 @default.
• W1201955184 hasConceptScore W1201955184C134018914 @default.
• W1201955184 hasConceptScore W1201955184C135763542 @default.
• W1201955184 hasConceptScore W1201955184C149737253 @default.
• W1201955184 hasConceptScore W1201955184C2777871287 @default.
• W1201955184 hasConceptScore W1201955184C2778754045 @default.
• W1201955184 hasConceptScore W1201955184C2779952775 @default.
• W1201955184 hasConceptScore W1201955184C2984496839 @default.
• W1201955184 hasConceptScore W1201955184C36823959 @default.
• W1201955184 hasConceptScore W1201955184C54355233 @default.
• W1201955184 hasConceptScore W1201955184C71315377 @default.
• W1201955184 hasConceptScore W1201955184C71924100 @default.
• W1201955184 hasConceptScore W1201955184C86803240 @default.
• W1201955184 hasIssue "6" @default.
• W1201955184 hasLocation W12019551841 @default.
• W1201955184 hasOpenAccess W1201955184 @default.
• W1201955184 hasPrimaryLocation W12019551841 @default.
• W1201955184 hasRelatedWork W1201955184 @default.
• W1201955184 hasRelatedWork W1994994219 @default.
• W1201955184 hasRelatedWork W2009766761 @default.
• W1201955184 hasRelatedWork W2019920503 @default.
• W1201955184 hasRelatedWork W2031280653 @default.
• W1201955184 hasRelatedWork W2048955825 @default.
• W1201955184 hasRelatedWork W2085823953 @default.
• W1201955184 hasRelatedWork W2161542386 @default.
• W1201955184 hasRelatedWork W2363973062 @default.
• W1201955184 hasRelatedWork W3029999682 @default.
• W1201955184 hasVolume "8" @default.
• W1201955184 isParatext "false" @default.
• W1201955184 isRetracted "false" @default.
• W1201955184 magId "1201955184" @default.
• W1201955184 workType "article" @default.