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- W1202167923 abstract "The tetrapyrrole biosynthesis pathway is broadly similar in all living systems, the first common intermediate being the highly reactive aminoketone, 5-aminolaevulinic acid. There are two totally distinct routes by which 5-aminolaevulinic acid is produced, one utilising the carbon skeleton of glutamate and the other involving glycine and succinyl-CoA. The glutamate, or C, pathway is found in many anaerobic bacteria and in plants, whereas the pathway using glycine and succinyl-CoA, although occurring in some bacteria, is mainly confined to animals and other eukaryotes. Once formed, 5-aminolaevulinic acid is transformed into the tetrapyrrole macrocycle in only three enzymic stages. This chapter discusses the enzymic synthesis of 5-aminolaevulinic acid and the subsequent three enzymic steps to porphobilinogen, preuroporphyrinogen and uroporphyrinogen III. These three stages are common to all living systems which synthesize tetrapyrroles." @default.
- W1202167923 created "2016-06-24" @default.
- W1202167923 creator A5076973969 @default.
- W1202167923 date "1991-01-01" @default.
- W1202167923 modified "2023-09-28" @default.
- W1202167923 title "Chapter 1 The biosynthesis of 5-aminolaevulinic acid and its transformation into uroporphyrinogen III" @default.
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