Matches in SemOpenAlex for { <https://semopenalex.org/work/W120232010> ?p ?o ?g. }
- W120232010 endingPage "25" @default.
- W120232010 startingPage "14" @default.
- W120232010 abstract "Embryonic stem (ES) cells undergo self-renewal and are pluripotent, i.e., they can give rise to all the types of specialised cells in the body. Scientific knowledge on ES cells is increasing rapidly, leading to opportunities for establishment of ES cell-based in vitro tests for drug discovery, preclinical safety pharmacology and toxicology. The main properties of ES cells making them useful in in vitro assays are that they have a normal diploid karyotype and can provide a large number of cells for high-throughput assays. Human ES cells additionally have the potential to provide solutions to problems related to interspecies differences and methods for screening for human polymorphisms, thus supporting robust human hazard identification and optimised drug discovery strategies. Importantly, ES cell based assays could be potential tools to reduce and perhaps replace, animal experiments. This chapter will describe ongoing research in the use of ES cells in toxicology and safety pharmacology, focusing on the major areas of progress, namely, embryotoxicology, cardiotoxicology and hepatoxicology." @default.
- W120232010 created "2016-06-24" @default.
- W120232010 creator A5053822823 @default.
- W120232010 creator A5084055140 @default.
- W120232010 date "2012-01-01" @default.
- W120232010 modified "2023-09-25" @default.
- W120232010 title "Embryonic Stem Cells in Safety Pharmacology and Toxicology" @default.
- W120232010 cites W1961499381 @default.
- W120232010 cites W1968928835 @default.
- W120232010 cites W1973807795 @default.
- W120232010 cites W1981457253 @default.
- W120232010 cites W1985370042 @default.
- W120232010 cites W1985800918 @default.
- W120232010 cites W1988671949 @default.
- W120232010 cites W1989333475 @default.
- W120232010 cites W1992837470 @default.
- W120232010 cites W2013483540 @default.
- W120232010 cites W2015301717 @default.
- W120232010 cites W2021807227 @default.
- W120232010 cites W2025080629 @default.
- W120232010 cites W2026281747 @default.
- W120232010 cites W2033284482 @default.
- W120232010 cites W2037497130 @default.
- W120232010 cites W2039651932 @default.
- W120232010 cites W2042538689 @default.
- W120232010 cites W2043195815 @default.
- W120232010 cites W2045899482 @default.
- W120232010 cites W2051635348 @default.
- W120232010 cites W2053883199 @default.
- W120232010 cites W2056521815 @default.
- W120232010 cites W2057159461 @default.
- W120232010 cites W2062971452 @default.
- W120232010 cites W2066478796 @default.
- W120232010 cites W2071311309 @default.
- W120232010 cites W2085021525 @default.
- W120232010 cites W2086943348 @default.
- W120232010 cites W2092647929 @default.
- W120232010 cites W2092749541 @default.
- W120232010 cites W2095748440 @default.
- W120232010 cites W2101819688 @default.
- W120232010 cites W2104155874 @default.
- W120232010 cites W2104209550 @default.
- W120232010 cites W2104269891 @default.
- W120232010 cites W2105035559 @default.
- W120232010 cites W2117597304 @default.
- W120232010 cites W2145137957 @default.
- W120232010 cites W2150861946 @default.
- W120232010 cites W2253109849 @default.
- W120232010 cites W2336375127 @default.
- W120232010 cites W27814405 @default.
- W120232010 cites W3021092633 @default.
- W120232010 cites W3049711239 @default.
- W120232010 cites W4213229536 @default.
- W120232010 cites W4213332588 @default.
- W120232010 cites W4231941867 @default.
- W120232010 cites W4242712068 @default.
- W120232010 cites W4242784351 @default.
- W120232010 cites W4242853928 @default.
- W120232010 cites W4300127172 @default.
- W120232010 doi "https://doi.org/10.1007/978-1-4614-3055-1_2" @default.
- W120232010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22437810" @default.
- W120232010 hasPublicationYear "2012" @default.
- W120232010 type Work @default.
- W120232010 sameAs 120232010 @default.
- W120232010 citedByCount "12" @default.
- W120232010 countsByYear W1202320102012 @default.
- W120232010 countsByYear W1202320102013 @default.
- W120232010 countsByYear W1202320102014 @default.
- W120232010 countsByYear W1202320102016 @default.
- W120232010 countsByYear W1202320102017 @default.
- W120232010 countsByYear W1202320102019 @default.
- W120232010 countsByYear W1202320102020 @default.
- W120232010 countsByYear W1202320102021 @default.
- W120232010 countsByYear W1202320102022 @default.
- W120232010 countsByYear W1202320102023 @default.
- W120232010 crossrefType "book-chapter" @default.
- W120232010 hasAuthorship W120232010A5053822823 @default.
- W120232010 hasAuthorship W120232010A5084055140 @default.
- W120232010 hasConcept C104317684 @default.
- W120232010 hasConcept C107459253 @default.
- W120232010 hasConcept C145103041 @default.
- W120232010 hasConcept C202751555 @default.
- W120232010 hasConcept C2776190711 @default.
- W120232010 hasConcept C2780035454 @default.
- W120232010 hasConcept C28328180 @default.
- W120232010 hasConcept C33070731 @default.
- W120232010 hasConcept C33618052 @default.
- W120232010 hasConcept C54355233 @default.
- W120232010 hasConcept C60644358 @default.
- W120232010 hasConcept C70721500 @default.
- W120232010 hasConcept C74187038 @default.
- W120232010 hasConcept C86803240 @default.
- W120232010 hasConcept C95444343 @default.
- W120232010 hasConcept C98274493 @default.
- W120232010 hasConceptScore W120232010C104317684 @default.
- W120232010 hasConceptScore W120232010C107459253 @default.
- W120232010 hasConceptScore W120232010C145103041 @default.
- W120232010 hasConceptScore W120232010C202751555 @default.