Matches in SemOpenAlex for { <https://semopenalex.org/work/W12038155> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W12038155 endingPage "256" @default.
- W12038155 startingPage "247" @default.
- W12038155 abstract "A series of impaired metabolic functions in Down Syndrome (DS) including glucose handling has been described. Recent information from positron emission tomography studies in DS patients and our finding of downregulated phosphoglucose isomerase (PGI) in fetal brain with DS by gene hunting using subtractive hybridization, made us investigate PGI, a key enzyme of glucose metabolism, in brain of patients with DS, Alzheimer's disease (AD) and controls. PGI and phosphofructokinase (PFK) activities were determined in frontal, parietal, temporal, occipital lobe and cerebellum of 9 controls, 9 patients with DS and 9 patients with AD. PGI activity in DS brain was significantly decreased in frontal, temporal lobe and cerebellum, comparable to controls in parietal lobe and elevated in occipital lobe. Brain PGI activity of patients with AD was comparable to controls in all regions tested, PFK, a rate limiting enzyme of glucose metabolism, was comparable between all brain regions of all three groups. Data of this study confirm impaired glucose metabolism in DS proposed in literature and found by positron emission tomography (PET) studies. We show that changes in glucose handling in patients with AD as evaluated by PET studies are not supported by our data, although not contradictory, as determinants other than glucose metabolizing enzymes as e.g. vascular factors and glucose transport may account for these findings. Changes of downregulated PGI found by subtractive hybridization at the transcriptional level in fetal DS brain along with our findings in DS brain regions suggest a strong specific link between glucose metabolism and DS rather than AD." @default.
- W12038155 created "2016-06-24" @default.
- W12038155 creator A5020132824 @default.
- W12038155 creator A5072010327 @default.
- W12038155 creator A5074097141 @default.
- W12038155 creator A5082644975 @default.
- W12038155 date "1999-01-01" @default.
- W12038155 modified "2023-09-23" @default.
- W12038155 title "Impaired brain glucose metabolism in patients with Down Syndrome" @default.
- W12038155 cites W1220066822 @default.
- W12038155 cites W1965998694 @default.
- W12038155 cites W1971816743 @default.
- W12038155 cites W1976863698 @default.
- W12038155 cites W1999298850 @default.
- W12038155 cites W2016401339 @default.
- W12038155 cites W2036267254 @default.
- W12038155 cites W2038310210 @default.
- W12038155 cites W2041789591 @default.
- W12038155 cites W2067116762 @default.
- W12038155 cites W2075375096 @default.
- W12038155 cites W2082665846 @default.
- W12038155 cites W2104759359 @default.
- W12038155 cites W2146729934 @default.
- W12038155 cites W2257637644 @default.
- W12038155 cites W2395716984 @default.
- W12038155 cites W3026551798 @default.
- W12038155 cites W4293247451 @default.
- W12038155 cites W4319705919 @default.
- W12038155 doi "https://doi.org/10.1007/978-3-7091-6380-1_16" @default.
- W12038155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10666680" @default.
- W12038155 hasPublicationYear "1999" @default.
- W12038155 type Work @default.
- W12038155 sameAs 12038155 @default.
- W12038155 citedByCount "12" @default.
- W12038155 countsByYear W120381552017 @default.
- W12038155 countsByYear W120381552019 @default.
- W12038155 countsByYear W120381552020 @default.
- W12038155 countsByYear W120381552021 @default.
- W12038155 countsByYear W120381552022 @default.
- W12038155 crossrefType "book-chapter" @default.
- W12038155 hasAuthorship W12038155A5020132824 @default.
- W12038155 hasAuthorship W12038155A5072010327 @default.
- W12038155 hasAuthorship W12038155A5074097141 @default.
- W12038155 hasAuthorship W12038155A5082644975 @default.
- W12038155 hasConcept C122245378 @default.
- W12038155 hasConcept C126322002 @default.
- W12038155 hasConcept C134018914 @default.
- W12038155 hasConcept C169760540 @default.
- W12038155 hasConcept C17093226 @default.
- W12038155 hasConcept C20251656 @default.
- W12038155 hasConcept C2775842073 @default.
- W12038155 hasConcept C2777127467 @default.
- W12038155 hasConcept C2778046553 @default.
- W12038155 hasConcept C2779652256 @default.
- W12038155 hasConcept C62231903 @default.
- W12038155 hasConcept C71924100 @default.
- W12038155 hasConcept C86803240 @default.
- W12038155 hasConceptScore W12038155C122245378 @default.
- W12038155 hasConceptScore W12038155C126322002 @default.
- W12038155 hasConceptScore W12038155C134018914 @default.
- W12038155 hasConceptScore W12038155C169760540 @default.
- W12038155 hasConceptScore W12038155C17093226 @default.
- W12038155 hasConceptScore W12038155C20251656 @default.
- W12038155 hasConceptScore W12038155C2775842073 @default.
- W12038155 hasConceptScore W12038155C2777127467 @default.
- W12038155 hasConceptScore W12038155C2778046553 @default.
- W12038155 hasConceptScore W12038155C2779652256 @default.
- W12038155 hasConceptScore W12038155C62231903 @default.
- W12038155 hasConceptScore W12038155C71924100 @default.
- W12038155 hasConceptScore W12038155C86803240 @default.
- W12038155 hasLocation W120381551 @default.
- W12038155 hasLocation W120381552 @default.
- W12038155 hasOpenAccess W12038155 @default.
- W12038155 hasPrimaryLocation W120381551 @default.
- W12038155 hasRelatedWork W12038155 @default.
- W12038155 hasRelatedWork W1873871307 @default.
- W12038155 hasRelatedWork W1969419739 @default.
- W12038155 hasRelatedWork W1994826134 @default.
- W12038155 hasRelatedWork W2041949500 @default.
- W12038155 hasRelatedWork W2063441939 @default.
- W12038155 hasRelatedWork W2076778956 @default.
- W12038155 hasRelatedWork W2405388983 @default.
- W12038155 hasRelatedWork W4362209258 @default.
- W12038155 hasRelatedWork W2072208752 @default.
- W12038155 isParatext "false" @default.
- W12038155 isRetracted "false" @default.
- W12038155 magId "12038155" @default.
- W12038155 workType "book-chapter" @default.