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- W12038825 abstract "Introduction: Aging is associated with increased activity of both the adrenergic and renin-angiotensin-aldosterone systems (RAAS), which may contribute to the well-known elevation in peripheral vasoconstriction with age, as well as the sequelae of geriatric hypertension. The individual contribution of each pathway may be exacerbated by the potentiating effects of ANG-II on alpha-adrenergic vasoconstriction, though this interaction has not been studied in healthy aging. Hypothesis: We hypothesized that: (1) Alpha-adrenergic vasoconstriction would be similar between young and older, and (2) ANG-II-mediated vasoconstriction would be greater in the elderly than in young, but this age effect would be ablated in the presence of alpha-adrenergic antagonism. Methods: Eleven subjects (n=6 young, 25±1 yrs; n=5 older, 65±1 yrs) underwent brachial artery catheterization for local administration of ANG-II (0.8–25 ng/dl/min), NE (2.5–80 ng/dl/min) and ANG-II with concomitant alpha adrenergic antagonism (phentolamine, 1..." @default.
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- W12038825 date "2010-11-23" @default.
- W12038825 modified "2023-10-17" @default.
- W12038825 title "Abstract 10269: Angiotensin II Potentiates α-Adrenergic Vasoconstriction in the Elderly" @default.
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