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- W12042310 abstract "To determine the (tttta)n repeat polymorphisms at the promoter region of CYP11a gene, and study its linkage to hyperandrogenism of polycystic ovary syndrome (PCOS) in Chinese women, a case-control study was conducted in the Reproductive Medical Center of the Second Affiliated Hospital of Zhengzhou University (Zhengzhou, China). 96 PCOS patients and 78 healthy control women were included. CYP11a (tttta)n repeat-polymorphism genotyping analysis was performed by using polymerase chain reaction (PCR). Serum pituitary hormone and total testosterone levels were measured by ELISA. 4 different CYP1 la (tttta)n allelles were identified, corresponding to 4-, 6-, 8-, and 9-repeat-unit alleles. The frequency and distribution of these alleles are 0. 16, 0.33, 0.38, and 0. 13 respectively in PCOS patients, as compared with 0. 20, 0. 34, 0. 35, and 0.11 respectively in healthy controls. There were no significant differences between these two groups. Moreover, no correlation between the polymorphism of CYP11a gene and serum testosterone level of patients with PCOS and controls was observed. It is concluded that microsatellite polymorphism (tttta)n of gene CYP11a exists in Chinese women and the polymorphism of CYP11a gene does not play an important role in the pathogenesis of Chinese patients with PCOS, especially in patients with hyperandrogenism." @default.
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- W12042310 date "2005-01-01" @default.
- W12042310 modified "2023-09-26" @default.
- W12042310 title "Role of the Pentanucleotide （tttta）n Polymorphisms of CYP11a Gene in the Pathogenesis of Hyperandrogenism in Chinese Women with Polycystic Ovary Syndrome" @default.
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