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- W120645188 abstract "Human ABCC1 is a member of the ATP-binding cassette (ABC) transporter superfamily and serves as an efflux pump to a wide variety of substrates. Similar to most other ABC transporters, ABCC1 consists of both membrane-spanning and nucleotide-binding domains which function coordinately to actively transport substrates with the energy provided by ATP hydrolysis. Different from many other ABC transporters, ABCC1 has an additional membrane-spanning domain which may be responsible for its dimerization as well as a putative gating function. ABCC1 is ubiquitously expressed and its substrates vary from anticancer drugs to conjugated organic anions to heavy metals. Thus, it likely protects normal tissues where it is expressed from environmental cytotoxins and also protects cancer cells from cytotoxicities of anticancer drugs. Inhibitors of ABCC1 have been discovered and many are in process of further development. In this chapter, we review the current knowledge and recent progress in the studies of ABCC1, its structure and mechanism of action, its role in physiologic protection and drug resistance, as well as the discovery of ABCC1 inhibitors for development as chemosensitizers for combinational therapy of human cancers." @default.
- W120645188 created "2016-06-24" @default.
- W120645188 creator A5000853108 @default.
- W120645188 creator A5045603980 @default.
- W120645188 creator A5065653136 @default.
- W120645188 date "2012-01-01" @default.
- W120645188 modified "2023-10-14" @default.
- W120645188 title "Biochemistry and Pharmacology of Human ABCC1/MRP1 and Its Role in Detoxification and in Multidrug Resistance of Cancer Chemotherapy" @default.
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