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- W12069715 abstract "This chapter summarizes various therapeutic interventions employing experimental APS models, which may have future clinical applications. In general, the relationship between bone marrow transplantation (BMT) and autoimmunity is bi-directional, where autoimmunity can be either transferred or eliminated by BMT, depending on the nature of both the recipient and the donor. The rational behind treating autoimmune diseases with BMT is based on the fact that these diseases may originate from defects in the hematopoietic stem cells, and therefore, the elimination of the pathogenic bone marrow followed by reconstitution with nonpathogenic bone marrow cells may lead to disease cure. Sex hormones and other hormones can affect the immune response and modify the expression of autoimmunity in both animals and humans. Bromocriptine (BRC), which is a dopamine agonist that suppresses prolactin secretion and has immunoregulatory property, has a suppressive effect on experimental APS since there was a reduction in in vivo autoantibodies production, as well as suppression in the disease manifestations. It is believed that BRC acts as an immunosuppressant of autoimmune phenomena via induction of natural nonspecific CD8 suppressor T cells. Intravenous immunoglobulins (IVIg) are also used for the treatment of several autoimmune diseases including immune thrombocytopenic purpura, Kawasaki disease, autoimmune vasculitis, and even SLE. In an animal model of APS induced by passive transfer of monoclonal mouse anticardiolipin antibodies, IVIg treatment resulted in significantly less fetal resorptions, in comparison to the untreated mice." @default.
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- W12069715 date "2002-01-01" @default.
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- W12069715 title "Novel Perspectives in the Treatment of the Antiphospholipid Syndrome —From Anticoagulation to Immunomodulation" @default.
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- W12069715 doi "https://doi.org/10.1016/b978-044450987-1/50038-3" @default.
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