FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W120820110> ?p ?o ?g. }

• W120820110 endingPage "3586" @default.
• W120820110 startingPage "3579" @default.
• W120820110 abstract "Abstract Gene knockout mice studies indicate that urokinase-type plasminogen activator (u-PA) is importantly involved in fibrinolysis, but its physiologic mechanism of action remains poorly understood. We postulated that platelets may be involved in this mechanism, as they carry a novel receptor for u-PA and a portion of the single-chain u-PA (scu-PA) intrinsic to blood is tightly associated with platelets. Therefore, plasminogen activation by platelet-associated u-PA was studied. When washed platelets were incubated with plasminogen, no plasmin was generated as detected by plasmin synthetic substrate (S2403) hydrolysis; however, after the addition of thrombin, but not other agonists, platelet-dependent plasminogen activation occurred. Plasminogen activation was surface-related, being inhibited by blocking platelet fibrinogen receptors or by preventing plasminogen binding to the thrombin-activated platelet surface. U-PA was identified as the only plasminogen activator responsible and enrichment of platelets with exogenous scu-PA significantly augmented plasminogen activation. These findings appeared paradoxical because thrombin inactivates scu-PA. Indeed, zymograms showed inactivation of scu-PA during the first hour of incubation with even the lowest dose of thrombin used (1 u/mL). However, this was followed by a thrombin dose-dependent (1 to 10 u/mL) partial return of u-PA activity. Reactivation of u-PA was not due to the direct action of thrombin, but required platelets and was found to be related to a platelet lysosomal thiol protease, consistent with cathepsin C. In conclusion, a new pathway of plasminogen activation by platelet-associated endogenous or exogenous scu-PA was demonstrated, which is specifically triggered by thrombin activation of platelets. These findings may help explain u-PA–mediated physiological fibrinolysis and have implications for therapeutic thrombolysis with scu-PA." @default.
• W120820110 created "2016-06-24" @default.
• W120820110 creator A5009650479 @default.
• W120820110 creator A5032001213 @default.
• W120820110 creator A5072882432 @default.
• W120820110 date "1997-11-01" @default.
• W120820110 modified "2023-10-03" @default.
• W120820110 title "Thrombin Stimulation of Platelets Induces Plasminogen Activation Mediated by Endogenous Urokinase-Type Plasminogen Activator" @default.
• W120820110 cites W122989367 @default.
• W120820110 cites W1493910160 @default.
• W120820110 cites W1530246363 @default.
• W120820110 cites W1532000327 @default.
• W120820110 cites W1552488548 @default.
• W120820110 cites W1559413326 @default.
• W120820110 cites W1595837188 @default.
• W120820110 cites W1965321286 @default.
• W120820110 cites W1974208990 @default.
• W120820110 cites W2001124978 @default.
• W120820110 cites W2005700271 @default.
• W120820110 cites W2016918804 @default.
• W120820110 cites W2017700181 @default.
• W120820110 cites W2022761196 @default.
• W120820110 cites W2038613606 @default.
• W120820110 cites W2040041623 @default.
• W120820110 cites W2053406741 @default.
• W120820110 cites W2055197581 @default.
• W120820110 cites W2056355602 @default.
• W120820110 cites W2073270498 @default.
• W120820110 cites W2075628446 @default.
• W120820110 cites W2085597582 @default.
• W120820110 cites W2086793123 @default.
• W120820110 cites W2088277704 @default.
• W120820110 cites W2100837269 @default.
• W120820110 cites W2236214807 @default.
• W120820110 cites W2272669184 @default.
• W120820110 cites W2320417794 @default.
• W120820110 cites W2409055602 @default.
• W120820110 cites W40278976 @default.
• W120820110 cites W4230684305 @default.
• W120820110 cites W4246999990 @default.
• W120820110 cites W4251962997 @default.
• W120820110 cites W4255323880 @default.
• W120820110 doi "https://doi.org/10.1182/blood.v90.9.3579" @default.
• W120820110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9345041" @default.
• W120820110 hasPublicationYear "1997" @default.
• W120820110 type Work @default.
• W120820110 sameAs 120820110 @default.
• W120820110 citedByCount "33" @default.
• W120820110 countsByYear W1208201102013 @default.
• W120820110 countsByYear W1208201102016 @default.
• W120820110 countsByYear W1208201102017 @default.
• W120820110 countsByYear W1208201102018 @default.
• W120820110 countsByYear W1208201102019 @default.
• W120820110 countsByYear W1208201102020 @default.
• W120820110 countsByYear W1208201102021 @default.
• W120820110 crossrefType "journal-article" @default.
• W120820110 hasAuthorship W120820110A5009650479 @default.
• W120820110 hasAuthorship W120820110A5032001213 @default.
• W120820110 hasAuthorship W120820110A5072882432 @default.
• W120820110 hasConcept C126322002 @default.
• W120820110 hasConcept C134018914 @default.
• W120820110 hasConcept C181199279 @default.
• W120820110 hasConcept C185592680 @default.
• W120820110 hasConcept C2776825266 @default.
• W120820110 hasConcept C2776892390 @default.
• W120820110 hasConcept C2777292125 @default.
• W120820110 hasConcept C2779679481 @default.
• W120820110 hasConcept C2781071845 @default.
• W120820110 hasConcept C3018697912 @default.
• W120820110 hasConcept C55493867 @default.
• W120820110 hasConcept C71924100 @default.
• W120820110 hasConcept C86803240 @default.
• W120820110 hasConcept C89560881 @default.
• W120820110 hasConceptScore W120820110C126322002 @default.
• W120820110 hasConceptScore W120820110C134018914 @default.
• W120820110 hasConceptScore W120820110C181199279 @default.
• W120820110 hasConceptScore W120820110C185592680 @default.
• W120820110 hasConceptScore W120820110C2776825266 @default.
• W120820110 hasConceptScore W120820110C2776892390 @default.
• W120820110 hasConceptScore W120820110C2777292125 @default.
• W120820110 hasConceptScore W120820110C2779679481 @default.
• W120820110 hasConceptScore W120820110C2781071845 @default.
• W120820110 hasConceptScore W120820110C3018697912 @default.
• W120820110 hasConceptScore W120820110C55493867 @default.
• W120820110 hasConceptScore W120820110C71924100 @default.
• W120820110 hasConceptScore W120820110C86803240 @default.
• W120820110 hasConceptScore W120820110C89560881 @default.
• W120820110 hasIssue "9" @default.
• W120820110 hasLocation W1208201101 @default.
• W120820110 hasOpenAccess W120820110 @default.
• W120820110 hasPrimaryLocation W1208201101 @default.
• W120820110 hasRelatedWork W1027934997 @default.
• W120820110 hasRelatedWork W120820110 @default.
• W120820110 hasRelatedWork W1491074751 @default.
• W120820110 hasRelatedWork W189462138 @default.
• W120820110 hasRelatedWork W2014249782 @default.
• W120820110 hasRelatedWork W2018891963 @default.
• W120820110 hasRelatedWork W2418768116 @default.

• next