Matches in SemOpenAlex for { <https://semopenalex.org/work/W120891136> ?p ?o ?g. }
- W120891136 endingPage "54" @default.
- W120891136 startingPage "445" @default.
- W120891136 abstract "MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three single nucleotide polymorphisms (SNPs) in the coding region (C3435T, C1236T and G2677T/A) are the most widely studied SNPs in MDR1 and have been related to substrate and inhibitor-dependent functional modifications in in vitro studies and reduced expression in tissues. The three SNPs exhibit the highest frequencies in Asian and Caucasians populations and the lowest in African populations. In regard to the clinical implications of MDR1 SNPs, it was found in large meta-analysis that C3435T SNP was associated with a slight increase in the susceptibility to ulcerative colitis and cancer and was related with slight modifications in tacrolimus pharmacokinetics and platinum-based chemotherapy response in lung cancer. On the other hand, C3435T SNP has shown controversial results in many other cases of disease susceptibility and drug pharmacokinetics where no meta-analyses have been performed. There is less information about C1236T and G2677T/A SNPs, which, although investigated in some diseases and drug pharmacokinetics, have a very limited number of published meta-analyses. Further studies should include analysis of the haplotype 1236T-2677T/A-3435T as well as other SNPs in MDR1, other transporters and drug metabolizers that may be related with the outcome variable." @default.
- W120891136 created "2016-06-24" @default.
- W120891136 creator A5036714819 @default.
- W120891136 date "2014-04-02" @default.
- W120891136 modified "2023-10-03" @default.
- W120891136 title "MDR1 (ABCB1) polymorphisms: functional effects and clinical implications." @default.
- W120891136 cites W123422070 @default.
- W120891136 cites W1551725906 @default.
- W120891136 cites W1934568163 @default.
- W120891136 cites W1966368641 @default.
- W120891136 cites W1967278221 @default.
- W120891136 cites W1967593196 @default.
- W120891136 cites W1968808154 @default.
- W120891136 cites W1969031451 @default.
- W120891136 cites W1972856183 @default.
- W120891136 cites W1975481605 @default.
- W120891136 cites W1990666294 @default.
- W120891136 cites W1991205228 @default.
- W120891136 cites W2002345475 @default.
- W120891136 cites W2008695042 @default.
- W120891136 cites W2016380061 @default.
- W120891136 cites W2017634527 @default.
- W120891136 cites W2020797749 @default.
- W120891136 cites W2026097288 @default.
- W120891136 cites W2027504487 @default.
- W120891136 cites W2027860611 @default.
- W120891136 cites W2032019184 @default.
- W120891136 cites W2032594391 @default.
- W120891136 cites W2055412274 @default.
- W120891136 cites W2057582519 @default.
- W120891136 cites W2058787857 @default.
- W120891136 cites W2058864686 @default.
- W120891136 cites W2062903959 @default.
- W120891136 cites W2063216262 @default.
- W120891136 cites W2063676575 @default.
- W120891136 cites W2064701493 @default.
- W120891136 cites W2065556102 @default.
- W120891136 cites W2066631565 @default.
- W120891136 cites W2067469832 @default.
- W120891136 cites W2067807895 @default.
- W120891136 cites W2068865770 @default.
- W120891136 cites W2069856161 @default.
- W120891136 cites W2072045050 @default.
- W120891136 cites W2081572478 @default.
- W120891136 cites W2092419590 @default.
- W120891136 cites W2093105834 @default.
- W120891136 cites W2102398377 @default.
- W120891136 cites W2102439415 @default.
- W120891136 cites W2108208897 @default.
- W120891136 cites W2117901243 @default.
- W120891136 cites W2118342649 @default.
- W120891136 cites W2132976616 @default.
- W120891136 cites W2133431701 @default.
- W120891136 cites W2133822852 @default.
- W120891136 cites W2141356899 @default.
- W120891136 cites W2146222838 @default.
- W120891136 cites W2149552150 @default.
- W120891136 cites W2164948976 @default.
- W120891136 cites W2402176064 @default.
- W120891136 cites W66842089 @default.
- W120891136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24687344" @default.
- W120891136 hasPublicationYear "2014" @default.
- W120891136 type Work @default.
- W120891136 sameAs 120891136 @default.
- W120891136 citedByCount "44" @default.
- W120891136 countsByYear W1208911362014 @default.
- W120891136 countsByYear W1208911362015 @default.
- W120891136 countsByYear W1208911362016 @default.
- W120891136 countsByYear W1208911362017 @default.
- W120891136 countsByYear W1208911362018 @default.
- W120891136 countsByYear W1208911362019 @default.
- W120891136 countsByYear W1208911362020 @default.
- W120891136 countsByYear W1208911362022 @default.
- W120891136 countsByYear W1208911362023 @default.
- W120891136 crossrefType "journal-article" @default.
- W120891136 hasAuthorship W120891136A5036714819 @default.
- W120891136 hasConcept C104317684 @default.
- W120891136 hasConcept C112705442 @default.
- W120891136 hasConcept C114851261 @default.
- W120891136 hasConcept C121608353 @default.
- W120891136 hasConcept C133936738 @default.
- W120891136 hasConcept C135763542 @default.
- W120891136 hasConcept C139275648 @default.
- W120891136 hasConcept C153209595 @default.
- W120891136 hasConcept C180754005 @default.
- W120891136 hasConcept C197754878 @default.
- W120891136 hasConcept C202751555 @default.
- W120891136 hasConcept C2776598434 @default.
- W120891136 hasConcept C2777469378 @default.
- W120891136 hasConcept C2778707650 @default.
- W120891136 hasConcept C2779907587 @default.
- W120891136 hasConcept C526805850 @default.
- W120891136 hasConcept C54355233 @default.
- W120891136 hasConcept C71924100 @default.
- W120891136 hasConcept C86803240 @default.
- W120891136 hasConcept C87644729 @default.
- W120891136 hasConcept C98274493 @default.
- W120891136 hasConceptScore W120891136C104317684 @default.