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• W1211643602 abstract "Research Article1 February 1991free access The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. I. Stamenkovic I. Stamenkovic Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author A. Aruffo A. Aruffo Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author M. Amiot M. Amiot Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author B. Seed B. Seed Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author I. Stamenkovic I. Stamenkovic Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author A. Aruffo A. Aruffo Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author M. Amiot M. Amiot Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author B. Seed B. Seed Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author Author Information I. Stamenkovic1, A. Aruffo1, M. Amiot1 and B. Seed1 1Department of Genetics, Harvard Medical School, Boston, MA. The EMBO Journal (1991)10:343-348https://doi.org/10.1002/j.1460-2075.1991.tb07955.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info CD44 is a polymorphic integral membrane protein which recognizes hyaluronate and whose proposed roles encompass lymphocyte activation, matrix adhesion and the attachment of lymphocytes to lymph node high endothelial venules (HEVs). Immunochemical and RNA blot data have supported the existence of two forms of CD44: a hematopoietic form expressed by cells of mesodermal origin (and by some carcinoma cell lines) and an epithelial form weakly expressed by normal epithelium but highly expressed by carcinomas. This report describes the isolation of a cDNA encoding a distinct CD44 polypeptide expressed by epithelial cells. Re-expression of each form of CD44 in a B cell line allowed cells transfected with the hematopoietic but not the epithelial form to bind to viable rat lymph node HEV cells in primary culture. Previous ArticleNext Article Volume 10Issue 21 February 1991In this issue RelatedDetailsLoading ..." @default.
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• W1211643602 title "The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells." @default.
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