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• W121339944 abstract "Research Article1 April 1988free access Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment. H. R. Pelham H. R. Pelham MRC Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author H. R. Pelham H. R. Pelham MRC Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author Author Information H. R. Pelham1 1MRC Laboratory of Molecular Biology, Cambridge, UK. The EMBO Journal (1988)7:913-918https://doi.org/10.1002/j.1460-2075.1988.tb02896.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Several soluble proteins that reside in the lumen of the ER contain a specific C-terminal sequence (KDEL) which prevents their secretion. This sequence may be recognized by a receptor that either immobilizes the proteins in the ER, or sorts them from other proteins at a later point in the secretory pathway and returns them to their normal location. To distinguish these possibilities, I have attached an ER retention signal to the lysosomal protein cathepsin D. The oligosaccharide side chains of this protein are normally modified sequentially by two enzymes to form mannose-6-phosphate residues; these enzymes do not act in the ER, but are thought to be located in separate compartments within (or near) the Golgi apparatus. Cathepsin D bearing the ER signal accumulates within the ER, but continues to be modified by the first of the mannose-6-phosphate forming enzymes. Modification is strongly temperature-dependent, which is also a feature of ER-to-Golgi transport. These results support the idea that luminal ER proteins are continuously retrieved from a post-ER compartment, and that this compartment contains N-acetylglucosaminyl-1-phosphotransferase activity. Previous ArticleNext Article Volume 7Issue 41 April 1988In this issue RelatedDetailsLoading ..." @default.
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• W121339944 date "1988-04-01" @default.
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• W121339944 title "Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment." @default.
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• W121339944 doi "https://doi.org/10.1002/j.1460-2075.1988.tb02896.x" @default.
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