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- W121353543 abstract "OBJECTIVE: To investigate the expression of matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-9 (MMP-9) and transforming growth factor-β1 (TGF-β1) in human pterygium and explore its clinical significance. METHODS: 60 primary pterygium (experiment group) and 24 normal conjunctiva (control group) specimens were collected. Expression of MMP-1, MMP-9 and TGF-β1 in two groups was detected using immunohistochemistry and RT-PCR method. RESULTS: Immunohistochemistry result shows that the positive products of MMP-1, MMP-9 and TGF-β1 can be found in all layers of pterygium, and overexpression in epithelium and hemoendothelial layer. The positive expression was stronger in experiment group than in control group. RT-PCR result shows that expression level of MMP-1 and MMP-9 was higher in experiment group than in control one. The difference was significant (P <0.05) CONCLUSION: The overexpression of MMP-1 and MMP-9 in primary pteryguim may associate with degradation of extracellular matrix, dissolution of Bowman’s layer those results in invasion of cornea. The overexpression of TGF-β1 may be related with hyperplasia of collagen fiber and accumulation of metamorphic fiber that lead to tissue apophysis." @default.
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- W121353543 date "2007-01-01" @default.
- W121353543 modified "2023-09-26" @default.
- W121353543 title "Expression of MMP‐1, MMP‐9 and TGF‐β1 in Human Pterygium and Its Clinical Significance" @default.
- W121353543 doi "https://doi.org/10.1096/fasebj.21.6.a766-b" @default.
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