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- W1214236412 endingPage "50" @default.
- W1214236412 startingPage "1" @default.
- W1214236412 abstract "Publisher Summary Antibody molecules are essentially required to carry out two principal roles in immune defense that are (i) to recognize and bind to foreign material (antigen) and (ii) to trigger the elimination of foreign material. The requirements imposed on the antibody molecule by the functions (i) and (ii) are in a sense quite opposite. Function (i) requires great antibody diversity. Function (ii) requires commonality, i.e. it is not practical for Nature to devise a different molecular solution for the problem of elimination for each different antibody molecule. In fact the conflicting requirements are elegantly met by the antibody structure. The structure consists of three units. Two of the units are identical and involved in binding to antigen - the Fab (fragment antigen binding) arms of the molecule. These units contain regions of sequence which vary greatly from one antibody t o another and confer on a given antibody its unique binding specificity. The existence of two Fab arms greatly enhances the affinity of antibody for antigen in the normal situation where multiple copies of antigenic determinants are presented to the host. The third unit - Fc (fragment crystalline) - is involved in binding to effector molecules." @default.
- W1214236412 created "2016-06-24" @default.
- W1214236412 creator A5058546353 @default.
- W1214236412 date "1987-01-01" @default.
- W1214236412 modified "2023-10-14" @default.
- W1214236412 title "Chapter 1 Structure and function of antibodies" @default.
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