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- W1216382008 abstract "This chapter reviews recent results concerning the transcriptional and post-transcriptional regulation of Drosophila Ddc and discusses the structure and regulation of the vertebrate amino acid decarboxylase (AADC) gene relative to Drosophila Ddc. Biogenic amines are decarboxylated derivatives of tyrosine and tryptophan that are found in animals from simple invertebrates to mammals. These compounds are found in neural tissue where they function as neurotransmitters and in non-neural tissues, where they have a variety of functions. The enzymes involved in biogenic amine synthesis and many receptors for these compounds have been isolated from both invertebrate and vertebrate sources. A key enzyme in biogenic amine biosynthesis is DOPA decarboxylase (DDC), also known as amino acid decarboxylase (AADC) in vertebrates. Functional cis-regulatory elements can be conserved between homologous genes of Drosophila and humans. In the hypoderm, Ddc expression leads to synthesis of dopamine that is further metabolized into quinones that have a vital function in the cross-linking, hardening, and pigmentation of the fly cuticle." @default.
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- W1216382008 date "1994-01-01" @default.
- W1216382008 modified "2023-10-16" @default.
- W1216382008 title "Regulation of the DOPA Decarboxylase Gene During Drosophila Development" @default.
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- W1216382008 doi "https://doi.org/10.1016/s1064-2722(08)60006-7" @default.
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