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- W121756857 abstract "Abstract Acute viral infections induce robust adaptive immune responses resulting in virus clearance. Recent evidence suggests that there may be depots of viral antigen which persist in draining lymph nodes following virus clearance and could therefore affect the adaptive immune response and memory formation. The nature of these residual antigen depots, the mechanism of antigen persistence and impact of the persistent antigen on memory T cells remains ill-defined. Employing a murine model of influenza virus infection of the respiratory tract, we have identified respiratory dendritic cells (RDC) as an essential cell responsible for both sampling and presenting residual viral antigen. RDC in the previously infected lung capture residual viral antigen deposited in an irradiation resistant cell type(s) and transport the viral antigen to the local lymph nodes draining the site of infection where the migrant RDC present the antigen to T cells. Furthermore, we demonstrate that there is preferential localization of memory T cells to the DLN following virus clearance as a consequence of presentation of residual viral antigen by the migrant RDC to T cells in the DLN. This enriched population of antigen-specific T cells maintained in the antigen draining LN would likely provide a more rapid and robust recall T cell response to a re-infection." @default.
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- W121756857 date "2010-04-01" @default.
- W121756857 modified "2023-09-26" @default.
- W121756857 title "Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells following acute virus infection (92.11)" @default.
- W121756857 doi "https://doi.org/10.4049/jimmunol.184.supp.92.11" @default.
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