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- W122013339 abstract "Planar microelectrode arrays (MEAs) have been used to provide a means for long-term, simultaneous recording of electrical activities from neural networks. Using microcontact printing, we produced grid neural networks on MEAs previously. However, action potentials were not always recorded from the electrodes even though neurons were observed on nearly the electrode sites. This inefficiency for functional recording sites may be an obstacle for optimal MEA use. One possible contributing factor for this observation is low neuron density since neurons in vitro may have far fewer synapses when compared to neurons in vivo. At lower densities neurons may not receive sufficient synaptic input to develop into functional networks. Therefore, we hypothesized that electrical stimulation on neural network might provide greater neurotransmitter release and promote neuronal growth. By using an ASIC chip, we developed a portable current stimulator which can deliver biphasic current stimulation with programmable parameters (amplitude: 2~1024 µA, pulse width: 10~320 µs, pulse rate: 10~800 Hz). The amplitude and pulse width were fixed within a safe range preventing neuronal cell death. And the effects of various stimulation rates were examined. After stimulating neurons for several days during culture days, neuronal clusters were produced around the stimulating electrode site. This result will be presented as a movie clip. We also accessed firing rates of signals recorded from the electrode. The neuronal clustering in neural networks were visualized by using immunocytochemistry." @default.
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- W122013339 date "2006-08-27" @default.
- W122013339 modified "2023-09-27" @default.
- W122013339 title "Electrical Stimulation Induced Neuronal Clustering in Cultured Neural Network" @default.
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