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- W122125007 abstract "We have developed a model of thrombosis to test in vivo the efficacy of antithrombotic agents in a microvascular network. The model involves the induction of a platelet thrombus within venules of the spinotrapezius muscle in anesthetized Sprague Dawley rats using a compound normally employed for microvascular oxygenation measurements (Pd-tetra-4-carboxyphenylporphyrin). The photoactive chemical is injected intravascularly and is excited with a 532 nm pulsed, Er:YAG laser ( 8-10 ?W, 0.4-0.6 kHz). As a result, free radicals are formed causing injury to the endothelial wall, subsequent platelet aggregation and thrombus formation without microvascular constriction. Red blood cell (RBC) velocity and intravascular diameter at thrombus site are monitored periodically. After testing venules of different sizes and RBC velocities, the most repeatable data were gathered from venules with diameters ranging from 40 to 60 µm and with RBC velocities ranging from 2 to 4 mm/sec. Upon establishing these control parameters, the model is being used to induce local ischemia and to test the effects of injected anti-thrombotic agents on platelet thrombus formation and local blood flow. Support: AD Willliams Trust Funds (VCU)." @default.
- W122125007 created "2016-06-24" @default.
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- W122125007 date "2009-04-01" @default.
- W122125007 modified "2023-10-14" @default.
- W122125007 title "Development of an animal model of microvascular thrombosis" @default.
- W122125007 doi "https://doi.org/10.1096/fasebj.23.1_supplement.593.13" @default.
- W122125007 hasPublicationYear "2009" @default.
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