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- W122180448 abstract "Les causes de purpura thrombotique thrombocytopénique (PTT) acquis sont multiples et d’origine médicamenteuse rare. Une femme de 40 ans co-infectée par le virus de l’immunodéficience humaine (VIH) et le virus de l’hépatite C (VHC) et traitée par interféron et ribavirine développait un tableau de PTT confirmé par la présence d’anticorps anti-ADAMTS 13. L’évolution était favorable à l’arrêt du traitement et après administration de rituximab. L’apparition d’une anémie et d’une thrombopénie sous interféron et ribavirine ne sont donc pas toujours liées à la toxicité directe de ces traitements. Le dosage de l’ADAMTS 13 peut permettre d’argumenter un diagnostic de PTT iatrogène. Causes of acquired thrombotic thrombocytopenic purpura (TTP) are multiple and rarely iatrogenic. A 40-year-old, HIV and hepatitis C virus co-infected woman was treated with interferon and ribavirine and developed a TTP confirmed by the presence of anti-ADAMTS 13 antibodies. The outcome was favourable when treatment was discontinued and rituximab infusion administered. The occurrence of anemia and thrombocytopenia in patients treated with interferon and ribavirine is not always related to direct toxicities of these treatments. The ADAMS 13 testing may help the clinician to diagnose iatrogenic acquired TTP." @default.
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- W122180448 date "2013-12-01" @default.
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- W122180448 title "Purpura thrombotique thrombocytopénique induit par l’interféron chez une femme co-infectée par le VIH et le VHC" @default.
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- W122180448 doi "https://doi.org/10.1016/j.revmed.2013.03.003" @default.
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