Matches in SemOpenAlex for { <https://semopenalex.org/work/W12218162> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W12218162 abstract "Long-term therapy with some anti-epileptic drugs, especially hPXR ligands, has been reported as a risk factor for osteomalacia. However, the mechanism has not been fully elucidated. In this study, we investigated the change of intestinal expression of CYP3A4, CYP24, TRPV6 (the gate-keeper in calcium absorption) with 1,25(OH)2D3 and/or rifampin treatment in cultured LS-180 cells and in vivo. Treatment of the cells with 1,25(OH)2D3 caused a 20-fold induction of TRPV6 expression. Moreover, we observed that a 20-fold increase in CYP3A4 expression with rifampin pre-treatment, prior to 1,25(OH)2D3 treatment, was associated with a 20% decrease in TRPV6 mRNA expression, compared to cells treated with 1,25(OH)2D3 alone. In vivo, duodenal biopsy samples from 5 healthy volunteers treated with rifampin exhibited similar results. There was a 6-fold increase in the duodenal CYP3A4 mRNA level and a 30% decrease in TRPV6 mRNA expression when subjects received rifampin (150 mg, q6h) for 14 days. In contrast, no significant change in the CYP24 mRNA level was detected after rifampin treatment both in vitro and in vivo. These findings suggest that an induction of CYP3A4 in human small intestine by hPXR ligand treatment might result in impaired calcium absorption, and therefore predispose individuals to bone demineralization and osteomalacia. Supported in part by grants from NIH: GM63666, ES07033, GM60364, GM38149 and RR000046." @default.
- W12218162 created "2016-06-24" @default.
- W12218162 creator A5004489015 @default.
- W12218162 creator A5008342397 @default.
- W12218162 creator A5012663330 @default.
- W12218162 creator A5013883984 @default.
- W12218162 creator A5056902004 @default.
- W12218162 creator A5062878299 @default.
- W12218162 creator A5078275283 @default.
- W12218162 date "2008-03-01" @default.
- W12218162 modified "2023-10-16" @default.
- W12218162 title "Dysregulation of intestinal CYP3A4‐dependent 1,25‐dihydroxyvitamin D3 catabolism: a potential mechanism for drug‐induced osteomalacia" @default.
- W12218162 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1135.3" @default.
- W12218162 hasPublicationYear "2008" @default.
- W12218162 type Work @default.
- W12218162 sameAs 12218162 @default.
- W12218162 citedByCount "0" @default.
- W12218162 crossrefType "journal-article" @default.
- W12218162 hasAuthorship W12218162A5004489015 @default.
- W12218162 hasAuthorship W12218162A5008342397 @default.
- W12218162 hasAuthorship W12218162A5012663330 @default.
- W12218162 hasAuthorship W12218162A5013883984 @default.
- W12218162 hasAuthorship W12218162A5056902004 @default.
- W12218162 hasAuthorship W12218162A5062878299 @default.
- W12218162 hasAuthorship W12218162A5078275283 @default.
- W12218162 hasConcept C109650736 @default.
- W12218162 hasConcept C124490489 @default.
- W12218162 hasConcept C126322002 @default.
- W12218162 hasConcept C134018914 @default.
- W12218162 hasConcept C150903083 @default.
- W12218162 hasConcept C155520015 @default.
- W12218162 hasConcept C179639408 @default.
- W12218162 hasConcept C185592680 @default.
- W12218162 hasConcept C207001950 @default.
- W12218162 hasConcept C2776541429 @default.
- W12218162 hasConcept C2777882243 @default.
- W12218162 hasConcept C2778049618 @default.
- W12218162 hasConcept C519063684 @default.
- W12218162 hasConcept C526171541 @default.
- W12218162 hasConcept C62231903 @default.
- W12218162 hasConcept C71924100 @default.
- W12218162 hasConcept C86803240 @default.
- W12218162 hasConcept C87975464 @default.
- W12218162 hasConcept C98274493 @default.
- W12218162 hasConceptScore W12218162C109650736 @default.
- W12218162 hasConceptScore W12218162C124490489 @default.
- W12218162 hasConceptScore W12218162C126322002 @default.
- W12218162 hasConceptScore W12218162C134018914 @default.
- W12218162 hasConceptScore W12218162C150903083 @default.
- W12218162 hasConceptScore W12218162C155520015 @default.
- W12218162 hasConceptScore W12218162C179639408 @default.
- W12218162 hasConceptScore W12218162C185592680 @default.
- W12218162 hasConceptScore W12218162C207001950 @default.
- W12218162 hasConceptScore W12218162C2776541429 @default.
- W12218162 hasConceptScore W12218162C2777882243 @default.
- W12218162 hasConceptScore W12218162C2778049618 @default.
- W12218162 hasConceptScore W12218162C519063684 @default.
- W12218162 hasConceptScore W12218162C526171541 @default.
- W12218162 hasConceptScore W12218162C62231903 @default.
- W12218162 hasConceptScore W12218162C71924100 @default.
- W12218162 hasConceptScore W12218162C86803240 @default.
- W12218162 hasConceptScore W12218162C87975464 @default.
- W12218162 hasConceptScore W12218162C98274493 @default.
- W12218162 hasFunder F4320332161 @default.
- W12218162 hasIssue "S1" @default.
- W12218162 hasLocation W122181621 @default.
- W12218162 hasOpenAccess W12218162 @default.
- W12218162 hasPrimaryLocation W122181621 @default.
- W12218162 hasRelatedWork W12218162 @default.
- W12218162 hasRelatedWork W2029670773 @default.
- W12218162 hasRelatedWork W2037727994 @default.
- W12218162 hasRelatedWork W2041470936 @default.
- W12218162 hasRelatedWork W2064236298 @default.
- W12218162 hasRelatedWork W2066508878 @default.
- W12218162 hasRelatedWork W2147487489 @default.
- W12218162 hasRelatedWork W2148772545 @default.
- W12218162 hasRelatedWork W2766470820 @default.
- W12218162 hasRelatedWork W3196353404 @default.
- W12218162 hasVolume "22" @default.
- W12218162 isParatext "false" @default.
- W12218162 isRetracted "false" @default.
- W12218162 magId "12218162" @default.
- W12218162 workType "article" @default.