Matches in SemOpenAlex for { <https://semopenalex.org/work/W122355242> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W122355242 endingPage "58" @default.
- W122355242 startingPage "49" @default.
- W122355242 abstract "Prostate cancers account for 43% of all cancers diagnosed in American men. It is estimated that in 1996, 317,000 new cases of prostate cancer were diagnosed and 41,000 men died of the disease. The challenge of treating prostate cancer lies in accurately distinguishing those histologically-localized cancers which will complete metastatic progression from those that will remain indolent. At this time, we lack appropriate histological markers to make such distinctions, therefore, it is often difficult to accurately predict the clinical course of an individual patient's disease. There is growing evidence that a critical event in the progression of a tumor cell from a non-metastatic to metastatic phenotype is the loss of function of metastasis-suppressor genes. These genes specifically suppress the ability of a cell to metastasize. Work from several groups has demonstrated that human chromosomes 8, 10, 11 and 17 encode prostate cancer metastasis suppressor activities. As a result of these efforts the first prostate cancer metastasis-suppressor gene, KAI1, was identified and mapped to the p11-2 region of chromosome 11. In subsequent studies, an additional gene encoded by the same region, CD44 was also determined to have metastasis-suppressor activity. Recent studies have shown a correlation between decreased expression of KAI1 and CD44 and an increased malignant potential of prostate cancers. It is anticipated that the identification of other metastasis suppressor genes may allow for the development of diagnostic markers useful in the clinical substaging of individual tumors. This manuscript is intended to present our perspective on the importance of these genes in the understanding of prostate cancer progression. More importantly, we present new findings from our laboratory's effort to identify the metastasis-suppressor genes encoded by human chromosome 17. Specifically we report the strategy currently being used to evaluate a series of candidate genes and the approach being utilized to pinpoint the metastasis-suppressor region on human chromosome 17." @default.
- W122355242 created "2016-06-24" @default.
- W122355242 creator A5001440897 @default.
- W122355242 creator A5022214779 @default.
- W122355242 creator A5036262725 @default.
- W122355242 creator A5047008450 @default.
- W122355242 creator A5060504369 @default.
- W122355242 creator A5065072795 @default.
- W122355242 creator A5066228012 @default.
- W122355242 creator A5077084069 @default.
- W122355242 creator A5091757658 @default.
- W122355242 date "1998-05-12" @default.
- W122355242 modified "2023-09-27" @default.
- W122355242 title "Prostate cancer metastasis-suppressor genes: a current perspective." @default.
- W122355242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9575426" @default.
- W122355242 hasPublicationYear "1998" @default.
- W122355242 type Work @default.
- W122355242 sameAs 122355242 @default.
- W122355242 citedByCount "12" @default.
- W122355242 countsByYear W1223552422012 @default.
- W122355242 countsByYear W1223552422022 @default.
- W122355242 crossrefType "journal-article" @default.
- W122355242 hasAuthorship W122355242A5001440897 @default.
- W122355242 hasAuthorship W122355242A5022214779 @default.
- W122355242 hasAuthorship W122355242A5036262725 @default.
- W122355242 hasAuthorship W122355242A5047008450 @default.
- W122355242 hasAuthorship W122355242A5060504369 @default.
- W122355242 hasAuthorship W122355242A5065072795 @default.
- W122355242 hasAuthorship W122355242A5066228012 @default.
- W122355242 hasAuthorship W122355242A5077084069 @default.
- W122355242 hasAuthorship W122355242A5091757658 @default.
- W122355242 hasConcept C121608353 @default.
- W122355242 hasConcept C126322002 @default.
- W122355242 hasConcept C142724271 @default.
- W122355242 hasConcept C143998085 @default.
- W122355242 hasConcept C1491633281 @default.
- W122355242 hasConcept C179185449 @default.
- W122355242 hasConcept C205003668 @default.
- W122355242 hasConcept C2776235491 @default.
- W122355242 hasConcept C2778025950 @default.
- W122355242 hasConcept C2778264664 @default.
- W122355242 hasConcept C2779013556 @default.
- W122355242 hasConcept C2779134260 @default.
- W122355242 hasConcept C2780192828 @default.
- W122355242 hasConcept C2780932548 @default.
- W122355242 hasConcept C2909960190 @default.
- W122355242 hasConcept C502942594 @default.
- W122355242 hasConcept C54355233 @default.
- W122355242 hasConcept C555283112 @default.
- W122355242 hasConcept C71924100 @default.
- W122355242 hasConcept C86803240 @default.
- W122355242 hasConcept C87874733 @default.
- W122355242 hasConceptScore W122355242C121608353 @default.
- W122355242 hasConceptScore W122355242C126322002 @default.
- W122355242 hasConceptScore W122355242C142724271 @default.
- W122355242 hasConceptScore W122355242C143998085 @default.
- W122355242 hasConceptScore W122355242C1491633281 @default.
- W122355242 hasConceptScore W122355242C179185449 @default.
- W122355242 hasConceptScore W122355242C205003668 @default.
- W122355242 hasConceptScore W122355242C2776235491 @default.
- W122355242 hasConceptScore W122355242C2778025950 @default.
- W122355242 hasConceptScore W122355242C2778264664 @default.
- W122355242 hasConceptScore W122355242C2779013556 @default.
- W122355242 hasConceptScore W122355242C2779134260 @default.
- W122355242 hasConceptScore W122355242C2780192828 @default.
- W122355242 hasConceptScore W122355242C2780932548 @default.
- W122355242 hasConceptScore W122355242C2909960190 @default.
- W122355242 hasConceptScore W122355242C502942594 @default.
- W122355242 hasConceptScore W122355242C54355233 @default.
- W122355242 hasConceptScore W122355242C555283112 @default.
- W122355242 hasConceptScore W122355242C71924100 @default.
- W122355242 hasConceptScore W122355242C86803240 @default.
- W122355242 hasConceptScore W122355242C87874733 @default.
- W122355242 hasIssue "1" @default.
- W122355242 hasLocation W1223552421 @default.
- W122355242 hasOpenAccess W122355242 @default.
- W122355242 hasPrimaryLocation W1223552421 @default.
- W122355242 hasRelatedWork W122355242 @default.
- W122355242 hasRelatedWork W1978656238 @default.
- W122355242 hasRelatedWork W1979517777 @default.
- W122355242 hasRelatedWork W2010102102 @default.
- W122355242 hasRelatedWork W2053886118 @default.
- W122355242 hasRelatedWork W2085659118 @default.
- W122355242 hasRelatedWork W2363344444 @default.
- W122355242 hasRelatedWork W2409213166 @default.
- W122355242 hasRelatedWork W2163763011 @default.
- W122355242 hasRelatedWork W2188425035 @default.
- W122355242 hasVolume "12" @default.
- W122355242 isParatext "false" @default.
- W122355242 isRetracted "false" @default.
- W122355242 magId "122355242" @default.
- W122355242 workType "article" @default.