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• W122379871 abstract "In discussing the usefulness of isolated tissues in the drug discovery process, as with any model utilized in the characterization of a potential new drug, the question of relevance must be ascertained. The biologist usually interprets the effects of a drug on isolated tissues or organs as an action at the receptor level. However, the question does not have to be targeted toward a particular cellular or mechanistic parameter; it can also be more global in nature, e.g., clinical significance in comparison to known active agents. Usually, the more that is known about a chemical entity or clinical disorder, the more relevant are the in vitro tissue screens (see Williams and Malick, this volume)." @default.
• W122379871 created "2016-06-24" @default.
• W122379871 creator A5044549421 @default.
• W122379871 date "1987-01-01" @default.
• W122379871 modified "2023-09-24" @default.
• W122379871 title "Use of Intact Tissue Preparations in the Drug Discovery Process" @default.
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• W122379871 doi "https://doi.org/10.1007/978-1-4612-4828-6_4" @default.
• W122379871 hasPublicationYear "1987" @default.
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