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• W122398169 abstract "Prior studies link dietary deficiency and genetic risk factors for Alzheimer's disease (AD). In the present report, mice expressing human apolipoprotein E4 (associated with increased risk of AD) and apolipoprotein E3 were subjected to a diet lacking folate and vitamin E, and containing iron as a pr o-oxidant. Consistent with prior studies, E4 mice displayed more phospho-tau than E3 mice prior to dietary challenge. The deficient diet increased phospho-tau in E4 but not E3 mice, which was prevented by S-adenosyl methionine supplementation. Since neurofibrillary tangles are comprised of phospho-tau, investigation of the impact of dietary deficiency and S-adenosyl methionine supplementation on neurofibrillary tangle formation are warranted." @default.
• W122398169 created "2016-06-24" @default.
• W122398169 creator A5000330352 @default.
• W122398169 creator A5022729293 @default.
• W122398169 creator A5059634441 @default.
• W122398169 date "2009-07-01" @default.
• W122398169 modified "2023-09-23" @default.
• W122398169 title "Dietary Deficiency in Folate and Vitamin E Under Conditions of Oxidative Stress Increases Phospho-Tau Levels: Potentiation by ApoE4 and Alleviation by S-Adenosylmethionine" @default.
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• W122398169 doi "https://doi.org/10.3233/jad-2009-1076" @default.
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