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- W1225320144 abstract "Immunosuppression is mandatory after solid organ transplantation between HLA mismatched individuals. It is a lifelong therapy that needs to be closely monitored to avoid under- and over-immunosuppression. For many drugs, pharmacokinetic monitoring has been proven to be beneficial. However, the therapeutic ranges are statistically derived surrogate markers for the effects that cannot predict the individual response of single patients. Better tailored immunosuppression biomarkers are needed that indicate immune activation. T cells are critically involved in organ rejection, and the means to assess their activation state may be promising to individualize immunosuppressive therapies. Activated T cells can be monitored with flow cytometry based on surface molecules that are typically up regulated or with molecules that are cleaved off the cell surface. Among these molecules are the interleukin-2 receptor (CD25); transferrin receptor (CD71); the T cell co-stimulatory molecules CD28, CD69, and CD154 and sCD30, which is a member of the TNF-alpha family. The effect of immunosuppressive drugs on T cell activation can be recorded with indirect cell function assays or by directly monitoring activated T cells in whole blood. Soluble proteins can be measured with immunoassays. This review provides a summary of the experimental and clinical studies investigating the potential of surface molecules as a tool for immune monitoring. It critically discusses the obstacles and shortcomings from an analytical and diagnostic perspective that are currently preventing their use in multicenter trials and clinical routine monitoring of transplant patients." @default.
- W1225320144 created "2016-06-24" @default.
- W1225320144 creator A5045318721 @default.
- W1225320144 creator A5089500425 @default.
- W1225320144 date "2016-03-01" @default.
- W1225320144 modified "2023-10-02" @default.
- W1225320144 title "Lymphocyte surface molecules as immune activation biomarkers" @default.
- W1225320144 cites W1493858831 @default.
- W1225320144 cites W1513053699 @default.
- W1225320144 cites W1528759359 @default.
- W1225320144 cites W1550113805 @default.
- W1225320144 cites W1813961098 @default.
- W1225320144 cites W1964369673 @default.
- W1225320144 cites W1966361690 @default.
- W1225320144 cites W1966632757 @default.
- W1225320144 cites W1969854175 @default.
- W1225320144 cites W1973318436 @default.
- W1225320144 cites W1978364729 @default.
- W1225320144 cites W1980430374 @default.
- W1225320144 cites W1983267344 @default.
- W1225320144 cites W1983315434 @default.
- W1225320144 cites W1983942239 @default.
- W1225320144 cites W1985973644 @default.
- W1225320144 cites W1987561108 @default.
- W1225320144 cites W1988909564 @default.
- W1225320144 cites W1989439033 @default.
- W1225320144 cites W1993147375 @default.
- W1225320144 cites W1994536360 @default.
- W1225320144 cites W2006570519 @default.
- W1225320144 cites W2006737461 @default.
- W1225320144 cites W2007190645 @default.
- W1225320144 cites W2011234378 @default.
- W1225320144 cites W2012077095 @default.
- W1225320144 cites W2015054928 @default.
- W1225320144 cites W2019124674 @default.
- W1225320144 cites W2026589026 @default.
- W1225320144 cites W2027775098 @default.
- W1225320144 cites W2029142216 @default.
- W1225320144 cites W2031434633 @default.
- W1225320144 cites W2034917465 @default.
- W1225320144 cites W2042431910 @default.
- W1225320144 cites W2044200141 @default.
- W1225320144 cites W2047023479 @default.
- W1225320144 cites W2051577841 @default.
- W1225320144 cites W2054384859 @default.
- W1225320144 cites W2056093579 @default.
- W1225320144 cites W2057369427 @default.
- W1225320144 cites W2061082190 @default.
- W1225320144 cites W2062251763 @default.
- W1225320144 cites W2065006357 @default.
- W1225320144 cites W2065603960 @default.
- W1225320144 cites W2068377827 @default.
- W1225320144 cites W2072747908 @default.
- W1225320144 cites W2073981103 @default.
- W1225320144 cites W2078700708 @default.
- W1225320144 cites W2079463014 @default.
- W1225320144 cites W2080439304 @default.
- W1225320144 cites W2081458625 @default.
- W1225320144 cites W2084354031 @default.
- W1225320144 cites W2084768576 @default.
- W1225320144 cites W2088563489 @default.
- W1225320144 cites W2091261824 @default.
- W1225320144 cites W2091872043 @default.
- W1225320144 cites W2092887266 @default.
- W1225320144 cites W2098223659 @default.
- W1225320144 cites W2101492664 @default.
- W1225320144 cites W2101893870 @default.
- W1225320144 cites W2113739450 @default.
- W1225320144 cites W2114808530 @default.
- W1225320144 cites W2119681042 @default.
- W1225320144 cites W2131635925 @default.
- W1225320144 cites W2136606025 @default.
- W1225320144 cites W2138105644 @default.
- W1225320144 cites W2140569243 @default.
- W1225320144 cites W2148360027 @default.
- W1225320144 cites W2151829671 @default.
- W1225320144 cites W2164836144 @default.
- W1225320144 cites W2166881903 @default.
- W1225320144 cites W2168950407 @default.
- W1225320144 cites W2170955899 @default.
- W1225320144 cites W2318070408 @default.
- W1225320144 cites W2322908635 @default.
- W1225320144 cites W2325605813 @default.
- W1225320144 cites W2329232834 @default.
- W1225320144 cites W2334700463 @default.
- W1225320144 cites W2374544857 @default.
- W1225320144 cites W1983592820 @default.
- W1225320144 doi "https://doi.org/10.1016/j.clinbiochem.2015.07.099" @default.
- W1225320144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26247177" @default.
- W1225320144 hasPublicationYear "2016" @default.
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