FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W122677060> ?p ?o ?g. }

• W122677060 endingPage "41" @default.
• W122677060 startingPage "34" @default.
• W122677060 abstract "Reactive oxygen species (ROS) are essential for pathogenic development of Sclerotinia sclerotiorum. A key question for S. sclerotiorum and many other pathogens concerns how fungi tolerate/dampen the oxidative environment during growth and pathogenesis. Regulatory components of oxidative stress include both enzymatic and non-enzymatic antioxidants. Catalases are a ubiquitous family of enzymes that play an important role in the enzymatic detoxification of ROS by converting hydrogen peroxide (H2O2) to water and molecular oxygen. The genome of the omnivorous pathogen S. sclerotiorum contains seven predicted catalase genes. In this study we evaluate and functionally characterize the type A catalase (Scat1) in S. sclerotiorum, whose expression is highly induced during host infection. Insertional inactivation of Scat1 (ΔScat1) resulted in hyperbranching of hyphae accompanied by slower growth and smaller sclerotia. ΔScat1 strains were attenuated in pathogenicity and rendered the fungus hypersensitive to Sodium dodecyl sulfate (SDS), as well as to osmotic and salt stresses. Unexpectedly, ΔScat1 exhibited increased tolerance to H2O2, suggesting that although a member of the catalase family, generally associated with amelioration of oxidative stress, Scat1 is probably not required for detoxification of this oxygen species and presumably has different function(s). ΔScat1 strains had a 2-fold decrease in ergosterol content, and overall lower sterol levels compared to the wild-type strain. These observations are consistent with increased resistance to the polyene drugs amphotericin-B and nystatin. Taken together, our results suggest Scat1 is involved in modulation of ROS in a manner that deviates from the detoxification of H2O2, alters membrane integrity and contributes to the pathogenic success of S. sclerotiorum." @default.
• W122677060 created "2016-06-24" @default.
• W122677060 creator A5022396334 @default.
• W122677060 creator A5030169015 @default.
• W122677060 creator A5067238674 @default.
• W122677060 creator A5080536679 @default.
• W122677060 date "2014-01-01" @default.
• W122677060 modified "2023-10-02" @default.
• W122677060 title "Sclerotinia sclerotiorum catalase SCAT1 affects oxidative stress tolerance, regulates ergosterol levels and controls pathogenic development" @default.
• W122677060 cites W1538015214 @default.
• W122677060 cites W1756280447 @default.
• W122677060 cites W1792835221 @default.
• W122677060 cites W1845564569 @default.
• W122677060 cites W1976516556 @default.
• W122677060 cites W1976641554 @default.
• W122677060 cites W1980978115 @default.
• W122677060 cites W1981408889 @default.
• W122677060 cites W2005744466 @default.
• W122677060 cites W2005791237 @default.
• W122677060 cites W2009398499 @default.
• W122677060 cites W2016891766 @default.
• W122677060 cites W2017319917 @default.
• W122677060 cites W2021599758 @default.
• W122677060 cites W2022202001 @default.
• W122677060 cites W2025278656 @default.
• W122677060 cites W2026766302 @default.
• W122677060 cites W2029923446 @default.
• W122677060 cites W2031129576 @default.
• W122677060 cites W2034332162 @default.
• W122677060 cites W2036077981 @default.
• W122677060 cites W2036451354 @default.
• W122677060 cites W2038006451 @default.
• W122677060 cites W2054011610 @default.
• W122677060 cites W2063519100 @default.
• W122677060 cites W2065662503 @default.
• W122677060 cites W2065724201 @default.
• W122677060 cites W2070654910 @default.
• W122677060 cites W2071357103 @default.
• W122677060 cites W2081751987 @default.
• W122677060 cites W2088422230 @default.
• W122677060 cites W2090072861 @default.
• W122677060 cites W2095305581 @default.
• W122677060 cites W2102898288 @default.
• W122677060 cites W2106882534 @default.
• W122677060 cites W2110958512 @default.
• W122677060 cites W2120641763 @default.
• W122677060 cites W2125121305 @default.
• W122677060 cites W2128606612 @default.
• W122677060 cites W2130708707 @default.
• W122677060 cites W2134909835 @default.
• W122677060 cites W2136753636 @default.
• W122677060 cites W2139328007 @default.
• W122677060 cites W2140786297 @default.
• W122677060 cites W2144149632 @default.
• W122677060 cites W2145224143 @default.
• W122677060 cites W2146052127 @default.
• W122677060 cites W2152156805 @default.
• W122677060 cites W2152422585 @default.
• W122677060 cites W2154820652 @default.
• W122677060 cites W2159143945 @default.
• W122677060 cites W2160330672 @default.
• W122677060 cites W2161990266 @default.
• W122677060 cites W2163096766 @default.
• W122677060 cites W2163187840 @default.
• W122677060 cites W2164671653 @default.
• W122677060 cites W2165099698 @default.
• W122677060 cites W2167717820 @default.
• W122677060 cites W2171801393 @default.
• W122677060 cites W2171822354 @default.
• W122677060 cites W2171872825 @default.
• W122677060 doi "https://doi.org/10.1016/j.pmpp.2013.12.001" @default.
• W122677060 hasPublicationYear "2014" @default.
• W122677060 type Work @default.
• W122677060 sameAs 122677060 @default.
• W122677060 citedByCount "36" @default.
• W122677060 countsByYear W1226770602015 @default.
• W122677060 countsByYear W1226770602016 @default.
• W122677060 countsByYear W1226770602017 @default.
• W122677060 countsByYear W1226770602018 @default.
• W122677060 countsByYear W1226770602019 @default.
• W122677060 countsByYear W1226770602020 @default.
• W122677060 countsByYear W1226770602021 @default.
• W122677060 countsByYear W1226770602022 @default.
• W122677060 countsByYear W1226770602023 @default.
• W122677060 crossrefType "journal-article" @default.
• W122677060 hasAuthorship W122677060A5022396334 @default.
• W122677060 hasAuthorship W122677060A5030169015 @default.
• W122677060 hasAuthorship W122677060A5067238674 @default.
• W122677060 hasAuthorship W122677060A5080536679 @default.
• W122677060 hasConcept C2776151105 @default.
• W122677060 hasConcept C2777910421 @default.
• W122677060 hasConcept C2778530245 @default.
• W122677060 hasConcept C2778979269 @default.
• W122677060 hasConcept C48349386 @default.
• W122677060 hasConcept C55493867 @default.
• W122677060 hasConcept C59822182 @default.
• W122677060 hasConcept C86803240 @default.
• W122677060 hasConcept C89423630 @default.

• next