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- W1226859623 abstract "The development of effective adjuvant is the key factor to boost the immunogenicity of tumor cells as a tumor vaccine. In this study, we expressed membrane-bound granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-18 (IL-18) as adjuvants in tumor cells to stimulate immune response. B7 transmembrane domain fused GM-CSF and IL-18 was successfully expressed in the cell membrane and stimulated mouse splenocyte proliferation. Co-expression of GM-CSF and IL-18 reduced tumorigenesis (P<0.05) and enhanced tumor protective efficacy (P<0.05) significantly in comparison with GM-CSF alone. These results indicated that the combination of GM-CSF andIL-18 will enhance the immunogenicity of a cell-based anti-tumor vaccine. This membrane-bound approach can be applied to other cytokines for the development of novel vaccine strategies." @default.
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- W1226859623 date "2015-07-17" @default.
- W1226859623 modified "2023-10-14" @default.
- W1226859623 title "Development of Membrane-Bound GM-CSF and IL-18 as an Effective Tumor Vaccine" @default.
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- W1226859623 doi "https://doi.org/10.1371/journal.pone.0133470" @default.
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