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- W122735657 abstract "It is well established that there are sex differences in the incidence and severity of cardiac defects in humans, and in a number of clinical and experimental studies it has been found that estrogen may play a cardioprotective role. However, in large-scale randomized, double-blind, placebo-controlled studies of hormone-replacement therapy (HRT) in menopausal women, both asymptomatic women and those with known coronary artery disease (CAD), the results have been disappointing. Alternatives to HRT are been sought, and selective estrogen receptor modulators (SERMs) with both estrogen antagonist effects in the breast and agonist effects in the heart that appear to be clinically safe, have recently begun to be used. The trancriptome and proteome analysis data has provided important molecular information on the sex-based differences observed in cardiac pathologies. There is growing evidence that epigenetic and environmental factors play a role in the persistent and heritable changes in the developing fetus that contribute to the etiology of cardiac diseases that might develop in adulthood and might be involved in the sexual dimorphism of several cardiac diseases." @default.
- W122735657 created "2016-06-24" @default.
- W122735657 creator A5022739391 @default.
- W122735657 date "2014-01-01" @default.
- W122735657 modified "2023-09-28" @default.
- W122735657 title "Gender and Cardiovascular Disease in the Post-Genomic Era" @default.
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