Matches in SemOpenAlex for { <https://semopenalex.org/work/W122809745> ?p ?o ?g. }
- W122809745 endingPage "326" @default.
- W122809745 startingPage "290" @default.
- W122809745 abstract "Summary Structurally diverse members of the ancient hemoglobin (Hb) superfamily show NO dioxygenase (NOD) activity (EC 1.14.12.17), suggesting a common and primal function for Hbs and myoglobins (Mbs). NO reacts rapidly with the oxy complexes of Hbs, Mbs, flavoHb, truncated Hb, legume Hb, and neuroglobin, generating stoichiometric ferric heme and nitrate, and incorporating both O-atoms of the bound O2. Associated flavin-containing reductases, cytochrome b5, or ascorbate reduce ferric heme to allow O2 rebinding and catalytic turnover. Hb functions as a true enzyme by controlling O2 binding and electrochemistry, by guiding NO diffusion and the dioxygenation reaction, and by shielding reactive Fe III − O 2 • , Fe III − OONO , Fe IV = O , and NO2 intermediates from solvent water and biomolecules. The activity protects against NO toxicity and modulates NO signaling in a variety of life forms. NODs and NOD inhibitors are finding applications in medicine, agriculture, and biotechnology." @default.
- W122809745 created "2016-06-24" @default.
- W122809745 creator A5045328721 @default.
- W122809745 creator A5060620520 @default.
- W122809745 date "2008-01-01" @default.
- W122809745 modified "2023-09-26" @default.
- W122809745 title "Nitric Oxide Dioxygenase: An Ancient Enzymic" @default.
- W122809745 cites W1002287009 @default.
- W122809745 cites W13011787 @default.
- W122809745 cites W1481105441 @default.
- W122809745 cites W1487416252 @default.
- W122809745 cites W1488493608 @default.
- W122809745 cites W1491103665 @default.
- W122809745 cites W1496441353 @default.
- W122809745 cites W1516415065 @default.
- W122809745 cites W1520353739 @default.
- W122809745 cites W1525224329 @default.
- W122809745 cites W1533933556 @default.
- W122809745 cites W1538474427 @default.
- W122809745 cites W1562287102 @default.
- W122809745 cites W1563052800 @default.
- W122809745 cites W1566126807 @default.
- W122809745 cites W1589413892 @default.
- W122809745 cites W1591245273 @default.
- W122809745 cites W1594268419 @default.
- W122809745 cites W1601173997 @default.
- W122809745 cites W160419203 @default.
- W122809745 cites W1652764779 @default.
- W122809745 cites W1653986885 @default.
- W122809745 cites W1668019941 @default.
- W122809745 cites W1798026767 @default.
- W122809745 cites W1798483425 @default.
- W122809745 cites W1821918060 @default.
- W122809745 cites W1922255305 @default.
- W122809745 cites W1935776831 @default.
- W122809745 cites W1942505014 @default.
- W122809745 cites W1963506195 @default.
- W122809745 cites W1964316765 @default.
- W122809745 cites W1964426558 @default.
- W122809745 cites W1964521153 @default.
- W122809745 cites W1964567064 @default.
- W122809745 cites W1965266053 @default.
- W122809745 cites W1965295255 @default.
- W122809745 cites W1965481505 @default.
- W122809745 cites W1965747774 @default.
- W122809745 cites W1966195969 @default.
- W122809745 cites W1967620110 @default.
- W122809745 cites W1968872901 @default.
- W122809745 cites W1969136884 @default.
- W122809745 cites W1971509945 @default.
- W122809745 cites W1971873200 @default.
- W122809745 cites W1972191076 @default.
- W122809745 cites W1972937083 @default.
- W122809745 cites W1973209401 @default.
- W122809745 cites W1974936925 @default.
- W122809745 cites W1975982125 @default.
- W122809745 cites W1976570771 @default.
- W122809745 cites W1977585507 @default.
- W122809745 cites W1979331188 @default.
- W122809745 cites W1980125903 @default.
- W122809745 cites W1980259297 @default.
- W122809745 cites W1982012152 @default.
- W122809745 cites W1983861507 @default.
- W122809745 cites W1984292350 @default.
- W122809745 cites W1984526892 @default.
- W122809745 cites W1984698654 @default.
- W122809745 cites W1984791958 @default.
- W122809745 cites W1984821281 @default.
- W122809745 cites W1986984015 @default.
- W122809745 cites W1987398418 @default.
- W122809745 cites W1989457736 @default.
- W122809745 cites W1989510040 @default.
- W122809745 cites W1989528698 @default.
- W122809745 cites W1990305352 @default.
- W122809745 cites W1990710075 @default.
- W122809745 cites W1990768518 @default.
- W122809745 cites W1991190924 @default.
- W122809745 cites W1991251241 @default.
- W122809745 cites W1991471023 @default.
- W122809745 cites W1991513944 @default.
- W122809745 cites W1991556936 @default.
- W122809745 cites W1992718978 @default.
- W122809745 cites W1993257224 @default.
- W122809745 cites W1995241084 @default.
- W122809745 cites W1995607458 @default.
- W122809745 cites W1999278302 @default.
- W122809745 cites W2000075945 @default.
- W122809745 cites W2000263337 @default.
- W122809745 cites W2000649747 @default.
- W122809745 cites W2000829850 @default.
- W122809745 cites W2000976830 @default.
- W122809745 cites W2001029839 @default.
- W122809745 cites W2001207916 @default.
- W122809745 cites W2001921526 @default.
- W122809745 cites W2003556769 @default.
- W122809745 cites W2003811454 @default.
- W122809745 cites W2004660089 @default.
- W122809745 cites W2005187114 @default.