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- W123048492 abstract "The structure of living cells is determined by their cytoskeleton, a complex system of linear protein polymers and associated macromolecules that provides internal mechanical support and several self-motion capabilities. Once believed to be an exclusive asset of eukaryotic cells, cytoskeletal polymers are now known to also exist in prokaryotes. Two families of proteins, all capable of polymerizing into filaments through nucleotide hydrolysis-dependent reactions, are the main constituents of cytoskeletons. Some of the filaments can in turn associate sidewise to form coarser fibrils or tubules. In addition, numerous associated proteins interconnect the filaments as bundles or networks, and mediate their interaction with other cell components. Specific molecular motors use energy-dependent conformational changes to walk along some cytoskeletal polymers, so they are capable of carrying organelles across the cytoplasm or developing tension if connected to fixed structures. As a result, cells can change in size, shape, internal arrangement, or location, according to their individual needs or functions. In recent years, the cytoskeleton has become the focus of increasing attention for biomedical research, as its direct etiological role in various diseases, or its potential as a target for alternative therapeutic action in other health disorders, is being explored." @default.
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- W123048492 date "2011-01-01" @default.
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- W123048492 title "Structural Organization of Cells – The Cytoskeleton" @default.
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