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- W1230587051 abstract "To the Editor: In the study by the Risk and Prevention Study Collaborative Group (May 9 issue),1 Roncaglioni et al. describe the cardiovascular effects of supplementation with 1 g of n–3 fatty acids on cardiovascular outcomes. The same dose was used and the same null difference in outcomes was found in the Outcome Reduction with an Initial Glargine Intervention (ORIGIN)2 trial. As in the ORIGIN trial, the authors used olive oil as a placebo. Olive oil is a source of monounsaturated fatty acids, which have been associated with beneficial changes in lipid metabolism and possibly with a reduced risk of incident events of coronary heart disease.2,3 I wonder whether the negative results of this trial could be explained by the relatively low dose of n–3 fatty acids and the comparison with a placebo that is actually not a true placebo but rather a source of fatty acids with beneficial effects. I think it is time to test the possibility that the pleiotropic effects of higher doses of n–3 fatty acids4 may be associated with a cardiovascular benefit." @default.
- W1230587051 created "2016-06-24" @default.
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- W1230587051 date "2013-08-22" @default.
- W1230587051 modified "2023-10-17" @default.
- W1230587051 title "n–3 Fatty Acids in Patients with Cardiac Risk Factors" @default.
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- W1230587051 doi "https://doi.org/10.1056/nejmc1308780" @default.
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