FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W123065863> ?p ?o ?g. }

• W123065863 abstract "The role of inflammation and anti-cyclic citrullinated peptide antibodies (anti-CCP) in the pathogenesis of cardiovascular disease in early rheumatoid arthritis (RA) remains unclear. Previous studies have suggested that both disease activity and disease duration are associated with atherosclerosis and a higher mortality rate caused primarily by coronary artery disease.We investigated how disease activity, anti-CCP status and coronary calcium score in treatment-naive early RA impacts left ventricular (LV) systolic function.Fifty-tree patients (30 women) with mean age 58.3±1.3 years and steroid- and disease-modifying antirheumatic drug (DMARD)-naive early RA were included. Disease activity was scored by the use of the Danish national DANBIO registry (number of swollen joints (NSJ (28)), number of tender joints (NTJ (28)), C-reactive protein (CRP) and Health Assessment Questionnaire (HAQ)). Pain, fatigue, patient and physician global assessment and a composite disease activity score (DAS28-CRP) were assessed by visual analog scales (VAS) 0-100. IgM rheumafactor (IgM-RF) and anti-CCP titers were evaluated by standardized techniques. Coronary calcium score was estimated by computed tomography by calculating the Agaston score. One experienced senior rheumatologist and one experienced cardiologist performed all the clinical assessments as well as all the transthoracic echocardiography (TTE) and coronary CT analysis.Disease activity scores before treatment at baseline were: NSJ (28) 7.1±2.7, NTJ (28) 8.5±3.5, CRP 11.7±12.9 mmol/l, HAQ 0.71±0.6, pain VAS 51.1±23.7, fatigue VAS 49.3±24.9, physician global assessment 54.2±15.0 and DAS28-CRP 4.8±0.7. Twenty-three (43%) patients were IgM-RF positive and 33 (62%) were anti-CCP positive. We found LV systolic function by conventional ejection fraction (EF) to be 54.1±9.2% and to be non-significant correlated to disease activity (CRP: r=0.07, p=0.64; baseline NSJ: r=-0.13, p=0.33; NTJ: r=-0.08, p=0.58; HAQ: r=0.23, p=0.1; pain VAS: r=-0.05, p=0.74; fatigue VAS: r=0.03, p=0,83; physician global assessment: r=-0.09, p=0.54 and DAS28: r=-0.03, p=0.84). However, using a more sensitive measurement of the LV function by global longitudinal systolic strain (GLS), we found a significant correlation: HAQ (r=0.29; p=0.037), patient global assessment by VAS (r=0.35; p=0.011), patient fatigue assessment by VAS (r=0.3; p=0.03) and DAS28-CRP (r=0.28; p=0.043); all corrected for relevant confounders (age, gender, pulse and blood pressure). Furthermore, anti-CCP was highly significantly correlated with GLS (r=-0.44; p=0.001) in univariate analysis. In multivariate analysis, it still remained significantly correlated (p=0.018), after correction for age, gender, pulse, and blood pressure. Using strain analysis of LV function, we found a significant difference in GLS in patients with high values of anti-CCP (titers ≥340) compared to patients with anti-CCP (titers <340); (-19.9±2.1% vs. -16.4±2.8%; p=0.0001). For patients with high IgM-RF, results were non-significant.We observed a significant correlation between increased disease activity and cardiac function in treatment-naive early RA." @default.
• W123065863 created "2016-06-24" @default.
• W123065863 creator A5023319473 @default.
• W123065863 creator A5033985460 @default.
• W123065863 creator A5048496472 @default.
• W123065863 creator A5086329383 @default.
• W123065863 date "2014-01-01" @default.
• W123065863 modified "2023-09-23" @default.
• W123065863 title "Left ventricular function in treatment-naive early rheumatoid arthritis." @default.
• W123065863 cites W1974356653 @default.
• W123065863 cites W1984520299 @default.
• W123065863 cites W1993160453 @default.
• W123065863 cites W1996168629 @default.
• W123065863 cites W2007510193 @default.
• W123065863 cites W2036959693 @default.
• W123065863 cites W2037882607 @default.
• W123065863 cites W2042227371 @default.
• W123065863 cites W2042391364 @default.
• W123065863 cites W2051728683 @default.
• W123065863 cites W2076532117 @default.
• W123065863 cites W2099225176 @default.
• W123065863 cites W2101139377 @default.
• W123065863 cites W2109967949 @default.
• W123065863 cites W2111350176 @default.
• W123065863 cites W2128952811 @default.
• W123065863 cites W2131381912 @default.
• W123065863 cites W2133136764 @default.
• W123065863 cites W2156122843 @default.
• W123065863 cites W2160427887 @default.
• W123065863 cites W2167939282 @default.
• W123065863 cites W64169420 @default.
• W123065863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4082232" @default.
• W123065863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25006535" @default.
• W123065863 hasPublicationYear "2014" @default.
• W123065863 type Work @default.
• W123065863 sameAs 123065863 @default.
• W123065863 citedByCount "11" @default.
• W123065863 countsByYear W1230658632015 @default.
• W123065863 countsByYear W1230658632017 @default.
• W123065863 countsByYear W1230658632018 @default.
• W123065863 countsByYear W1230658632019 @default.
• W123065863 countsByYear W1230658632020 @default.
• W123065863 countsByYear W1230658632022 @default.
• W123065863 crossrefType "journal-article" @default.
• W123065863 hasAuthorship W123065863A5023319473 @default.
• W123065863 hasAuthorship W123065863A5033985460 @default.
• W123065863 hasAuthorship W123065863A5048496472 @default.
• W123065863 hasAuthorship W123065863A5086329383 @default.
• W123065863 hasConcept C126322002 @default.
• W123065863 hasConcept C14184104 @default.
• W123065863 hasConcept C164705383 @default.
• W123065863 hasConcept C1862650 @default.
• W123065863 hasConcept C198451711 @default.
• W123065863 hasConcept C2777575956 @default.
• W123065863 hasConcept C2778143017 @default.
• W123065863 hasConcept C2778213512 @default.
• W123065863 hasConcept C2779134260 @default.
• W123065863 hasConcept C71924100 @default.
• W123065863 hasConceptScore W123065863C126322002 @default.
• W123065863 hasConceptScore W123065863C14184104 @default.
• W123065863 hasConceptScore W123065863C164705383 @default.
• W123065863 hasConceptScore W123065863C1862650 @default.
• W123065863 hasConceptScore W123065863C198451711 @default.
• W123065863 hasConceptScore W123065863C2777575956 @default.
• W123065863 hasConceptScore W123065863C2778143017 @default.
• W123065863 hasConceptScore W123065863C2778213512 @default.
• W123065863 hasConceptScore W123065863C2779134260 @default.
• W123065863 hasConceptScore W123065863C71924100 @default.
• W123065863 hasLocation W1230658631 @default.
• W123065863 hasOpenAccess W123065863 @default.
• W123065863 hasPrimaryLocation W1230658631 @default.
• W123065863 hasRelatedWork W1974356653 @default.
• W123065863 hasRelatedWork W2004065584 @default.
• W123065863 hasRelatedWork W2034908016 @default.
• W123065863 hasRelatedWork W2099225176 @default.
• W123065863 hasRelatedWork W2136669345 @default.
• W123065863 hasRelatedWork W2152572073 @default.
• W123065863 hasRelatedWork W2156122843 @default.
• W123065863 hasRelatedWork W2167939282 @default.
• W123065863 hasRelatedWork W2184672283 @default.
• W123065863 hasRelatedWork W2319857254 @default.
• W123065863 hasRelatedWork W2323630928 @default.
• W123065863 hasRelatedWork W2324572402 @default.
• W123065863 hasRelatedWork W2332440380 @default.
• W123065863 hasRelatedWork W2552266393 @default.
• W123065863 hasRelatedWork W2847122055 @default.
• W123065863 hasRelatedWork W2911099373 @default.
• W123065863 hasRelatedWork W3033439062 @default.
• W123065863 hasRelatedWork W3035406365 @default.
• W123065863 hasRelatedWork W3164973195 @default.
• W123065863 hasRelatedWork W410817826 @default.
• W123065863 isParatext "false" @default.
• W123065863 isRetracted "false" @default.
• W123065863 magId "123065863" @default.
• W123065863 workType "article" @default.