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- W123109712 abstract "Publisher Summary Removal of renal tissue stimulates prompt functional and anatomical adaptation in the remaining renal parenchyma. Functional adaptation after uninephrectomy includes rapid increases in fractional excretion of water, sodium, potassium, and bicarbonate by the intact kidney. This chapter discusses renal hemodynamic changes after elimination of one kidney. It explains that after unilateral nephrectomy (UNX), both glomerular filtration rate (GFR) and renal plasma flow (RPF) increase in the remnant kidney with regard to the left kidney of sham operated (SO) rats, being the adaptative response of RBF larger than the one for GFR, which leads to a fall in filtration fraction (FF). There is an increase of cardiac output with a similar fall in peripheric vascular resistances 48 hours after removal of one kidney. From the microsphere and micropuncture data a redistribution of blood flow and filtration rate to the superficial glomeruli is deduced. Single glomerulus blood flow is increased in the outer and inner cortex without changes for the midcortex whereas the rate superficial single nephron glomerular filtration rate/mean nephron GFR are increased in the UNX with respect to the SO rats. Results presented in the chapter suggest that important increases of filtered load of water and solutes and increased water and electrolyte excretion, as demonstrated by the rise in UV and FeNa, occur after UNX." @default.
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- W123109712 date "1981-01-01" @default.
- W123109712 modified "2023-09-27" @default.
- W123109712 title "GENERAL AND INTRARENAL HEMODYNAMIC ALTERATIONS AFTER UNILATERAL NEPHRECTOMY IN RATS" @default.
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- W123109712 doi "https://doi.org/10.1016/b978-0-08-026824-8.50028-x" @default.
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