Matches in SemOpenAlex for { <https://semopenalex.org/work/W1231316025> ?p ?o ?g. }
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- W1231316025 startingPage "1401" @default.
- W1231316025 abstract "The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an efficient and pivotal line of defensive to counteract environmental insults and endogenous stressors. Nrf2 coordinates the basal and inducible expression of antioxidant and Phase II detoxification enzymes to adapt to different stress conditions. The stability and cellular distribution of Nrf2 is tightly controlled by its inhibitory binding protein Kelch-like ECH-associated protein 1. Nrf2 signalling is also regulated by posttranslational, transcriptional, translational and epigenetic mechanisms, as well as by other protein partners, including p62, p21 and IQ motif-containing GTPase activating protein 1. Many studies have demonstrated that Nrf2 is a promising target for preventing carcinogenesis and other chronic diseases, including cardiovascular diseases, neurodegenerative diseases and pulmonary injury. However, constitutive activation of Nrf2 in advanced cancer cells may confer drug resistance. Here, we review the molecular mechanisms of Nrf2 signalling, the diverse classes of Nrf2 activators, including bioactive nutrients and other chemicals, and the cellular functions and disease relevance of Nrf2 and discuss the dual role of Nrf2 in different contexts." @default.
- W1231316025 created "2016-06-24" @default.
- W1231316025 creator A5002961841 @default.
- W1231316025 creator A5035435584 @default.
- W1231316025 creator A5080076598 @default.
- W1231316025 creator A5083349998 @default.
- W1231316025 date "2015-12-01" @default.
- W1231316025 modified "2023-10-04" @default.
- W1231316025 title "The complexity of the Nrf2 pathway: beyond the antioxidant response" @default.
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