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- W1232693927 abstract "Medical research in regenerative medicine and cell-based therapy has brought encouraging perspectives for the use of stem cells in clinical trials. Multiple types of stem cells, from progenitors to pluripotent stem cells, have been investigated. Among these, dental pulp stem cells (DPSCs) are mesenchymal multipotent cells coming from the dental pulp, which is the soft tissue within teeth. They represent an interesting adult stem cell source because they are recovered in large amount in dental pulps with non-invasive techniques compared to other adult stem cell sources. DPSCs can be obtained from discarded teeth, especially wisdom teeth extracted for orthodontic reasons. To shift from promising preclinical results to therapeutic applications to human, DPSCs must be prepared in clinical grade lots and transformed into advanced therapy medicinal products (ATMP). As the production of patient-specific stem cells is costly and time-consuming, allogenic biobanking of clinical grade human leukocyte antigen (HLA)-typed DPSC lines provides efficient innovative therapeutic products. DPSC biobanks represent industrial and therapeutic innovations by using discarded biological tissues (dental pulps) as a source of mesenchymal stem cells to produce and store, in good manufacturing practice (GMP) conditions, DPSC therapeutic batches. In this review, we discuss about the challenges to transfer biological samples from a donor to HLA-typed DPSC therapeutic lots, following regulations, GMP guidelines and ethical principles. We also present some clinical applications, for which there is no efficient therapeutics so far, but that DPSCs-based ATMP could potentially treat." @default.
- W1232693927 created "2016-06-24" @default.
- W1232693927 creator A5016211947 @default.
- W1232693927 creator A5038938912 @default.
- W1232693927 creator A5058056426 @default.
- W1232693927 creator A5085684624 @default.
- W1232693927 date "2015-08-26" @default.
- W1232693927 modified "2023-09-30" @default.
- W1232693927 title "Allogenic banking of dental pulp stem cells for innovative therapeutics." @default.
- W1232693927 cites W104792478 @default.
- W1232693927 cites W1485794983 @default.
- W1232693927 cites W1508128143 @default.
- W1232693927 cites W1510479414 @default.
- W1232693927 cites W15526706 @default.
- W1232693927 cites W1646076129 @default.
- W1232693927 cites W1796744353 @default.
- W1232693927 cites W1889663678 @default.
- W1232693927 cites W1956142447 @default.
- W1232693927 cites W1964302348 @default.
- W1232693927 cites W1964807970 @default.
- W1232693927 cites W1965430669 @default.
- W1232693927 cites W1969417678 @default.
- W1232693927 cites W1969696192 @default.
- W1232693927 cites W1969974679 @default.
- W1232693927 cites W1974610674 @default.
- W1232693927 cites W1977676780 @default.
- W1232693927 cites W1983474398 @default.
- W1232693927 cites W1989144555 @default.
- W1232693927 cites W1991936258 @default.
- W1232693927 cites W1992556222 @default.
- W1232693927 cites W1993326869 @default.
- W1232693927 cites W1993910454 @default.
- W1232693927 cites W1998650056 @default.
- W1232693927 cites W1998795940 @default.
- W1232693927 cites W2001895901 @default.
- W1232693927 cites W2006510884 @default.
- W1232693927 cites W2008056703 @default.
- W1232693927 cites W2008394861 @default.
- W1232693927 cites W2011422107 @default.
- W1232693927 cites W2011780217 @default.
- W1232693927 cites W2013729017 @default.
- W1232693927 cites W2013970253 @default.
- W1232693927 cites W2014646480 @default.
- W1232693927 cites W2015375064 @default.
- W1232693927 cites W2015725078 @default.
- W1232693927 cites W2019635786 @default.
- W1232693927 cites W2024235155 @default.
- W1232693927 cites W2024579131 @default.
- W1232693927 cites W2024919111 @default.
- W1232693927 cites W2025371271 @default.
- W1232693927 cites W2025950643 @default.
- W1232693927 cites W2027012204 @default.
- W1232693927 cites W2027130373 @default.
- W1232693927 cites W2030187900 @default.
- W1232693927 cites W2030713086 @default.
- W1232693927 cites W2033927170 @default.
- W1232693927 cites W2034833973 @default.
- W1232693927 cites W2035706135 @default.
- W1232693927 cites W2035976926 @default.
- W1232693927 cites W2036489800 @default.
- W1232693927 cites W2036550391 @default.
- W1232693927 cites W2036819945 @default.
- W1232693927 cites W2038777331 @default.
- W1232693927 cites W2040949741 @default.
- W1232693927 cites W2041308307 @default.
- W1232693927 cites W2042832662 @default.
- W1232693927 cites W2044072165 @default.
- W1232693927 cites W2044596336 @default.
- W1232693927 cites W2044810442 @default.
- W1232693927 cites W2053911973 @default.
- W1232693927 cites W2054274983 @default.
- W1232693927 cites W2055377478 @default.
- W1232693927 cites W2056274924 @default.
- W1232693927 cites W2058466588 @default.
- W1232693927 cites W2067079668 @default.
- W1232693927 cites W2073124183 @default.
- W1232693927 cites W2073910979 @default.
- W1232693927 cites W2075829691 @default.
- W1232693927 cites W2076972467 @default.
- W1232693927 cites W2078489918 @default.
- W1232693927 cites W2079359974 @default.
- W1232693927 cites W2085874330 @default.
- W1232693927 cites W2087993338 @default.
- W1232693927 cites W2088108906 @default.
- W1232693927 cites W2093267077 @default.
- W1232693927 cites W2093947534 @default.
- W1232693927 cites W2095298261 @default.
- W1232693927 cites W2100155649 @default.
- W1232693927 cites W2104357914 @default.
- W1232693927 cites W2106413293 @default.
- W1232693927 cites W2108732901 @default.
- W1232693927 cites W2109939725 @default.
- W1232693927 cites W2115635465 @default.
- W1232693927 cites W2116826060 @default.
- W1232693927 cites W2116864112 @default.
- W1232693927 cites W2117008800 @default.
- W1232693927 cites W2117762720 @default.
- W1232693927 cites W2121039238 @default.