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- W1236427863 abstract "Evidence for the presence of cytomegaloviruses (CMV) as pathogenic agents in man was first obtained by examination of tissues derived from still-born infants that demonstrated severe developmental abnormalities (Jesionek and Kiolemenoglou, 1904; Ribbert, 1904; Lowenstein, 1907). The salivary glands and other tissues of these infants contained enlarged cells with prominent nuclear inclusions (NI) that were eventually recognized as pathognomonic for this disease, i.e., cytomegalic inclusion disease (CID). It was not until about half a century after the initial descriptions of the cytomegalic cells that the virus responsible for these manifestations was isolated and partially characterized (Smith, 1956; Rowe et al., 1956, Weller et al., 1957). Cell cultures infected with freshly isolated or laboratory-adapted CMV demonstrated the characteristic enlarged cells with eosinophilic NI (Weller et al., 1957). Noting the unique and characteristic features of the cytopathology induced by these viruses, Weller et al. (1960) suggested that this group of viruses be renamed cytomegaloviruses (CMV).KeywordsHuman CytomegalovirusHerpes Simplex VirusPremature Chromosome CondensationAbortive InfectionCytomegalic Inclusion DiseaseThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W1236427863 created "2016-06-24" @default.
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- W1236427863 date "1989-01-01" @default.
- W1236427863 modified "2023-10-16" @default.
- W1236427863 title "Cell-activation responses to cytomegalovirus infection relationship to the phasing of CMV replication and to the induction of cellular damage." @default.
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