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- W12370908 abstract "NK cells recently have been shown to be key elements in several types of innate immune responses contributing to the elimination of tumor cells and genetically disparate cells. Furthermore, they can interfere with the regulation of acquired immune responses. In man, mouse, and rat, major families of NK cell membrane receptors are encoded by a particular chromosomal region, the natural killer gene complex (NKC). Using a newly developed congenic rat strain, LEW.NKC(BS), carrying the NKC of strain BS on the genetic background of strain LEW, we have now studied the genetic polymorphism of the NKR-P1B NK receptor and have generated a monoclonal antibody, HT31, detecting the NKR-P1B gene product of the LEW strain. Results: (1) In the strain combination LEW.NKC(BS)-anti-LEW the NKR-P1B receptor molecule is highly immunogenic. (2) The monoclonal antibody HT31 detects NKR- P1B on a subset of NK cells and on monocytes and macrophages but not on CD8 T cells. Thus, its expression pattern is clearly different from that of the well known NKR-P1A receptor. (3) The NKR-P1B receptors of LEW and LEW.NKC(BS) differ in 34 amino acid substitutions. (4) NKR-P1B inhibits NK cell functions. Conclusion: As NKR-P1B is expressed on cells of the monocyte-macrophage-lineage, its marked immunogenicity could affect the fate of antigen-presenting-cells in organ transplants between strains with different NKR-P1B alleles (accelerated elimination of APC). Furthermore, the data are important for a detailed functional analysis of NKR-P1B in innate immune responses." @default.
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- W12370908 date "2005-08-22" @default.
- W12370908 modified "2023-09-27" @default.
- W12370908 title "NKR-P1B Rezeptoren der Ratte sind polymorph und wirken als Alloantigen" @default.
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- W12370908 doi "https://doi.org/10.1007/3-540-26560-0_4" @default.
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