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- W123742254 abstract "CM1 (centrocyte/-blast marker I) defined by a monoclonal antibody developed against concanavalin-A activated PBMC (peripheral blood mononuclear cell),is expressed specifically on a subpopulation of centroblasts and centrocytes of human germinal center (GC) B cells. We observed the existence of CM1 in human lung cancer tissue. So we investigated the function of CM1 in lung cancer cell lines (A549). We observed that CM1 ligation with anti-CM1 mAb enhanced the apoptosis of A549 cells. And CM1 ligation induced the expression of both FasL and Fas in theses cells. Furthermore, both anti-Fas blocking antibody, ZB4, and anti-Fas ligand antibody NOK-1 blocked CM1-mediated apoptosis effectively. Caspase-8 inhibitor, z-IETD effectively blocked CM1-induced cell death. Western blot analysis showed down-regulated expression of procaspase-8 and PARP. The release of cytochrome c and translocation to nucleus of endoG and AIF were showed by confocal micoscopy. The findings suggested that Fas/FasL pathway was activated by CM1 ligation on human lung cancer cell line." @default.
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- W123742254 date "2008-03-01" @default.
- W123742254 modified "2023-09-27" @default.
- W123742254 title "CM1 ligation induces the apoptosis of human lung cancer cells via Fas/FasL interaction" @default.
- W123742254 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1079.12" @default.
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