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- W123766367 abstract "This chapter discusses the natural resistance against mouse hepatitis virus 3. In a study described in the chapter, A/J strain mice were obtained and A/J newborns were bred in mouse colony. Mice of the A/J strain are resistant to MHV3 infection when tested after 3 weeks of age, whereas 100% of A/J neonates die in 5 to 7 days when infected during the first 2 weeks of life. Mice were injected with one dose of 100 μCi 89Sr intraperitoneally and were utilized 4 weeks later. All suspensions were obtained from normal or from 89Sr-treated adult A/J mice. Whole spleen cells, adherent spleen cells, nylon wool-separated spleen cells (T lymphocytes), and bone marrow cells were prepared. MHV3 was passaged in susceptible DBA mice and on L cells. Virus titer was expressed either in LD50 or in tissue culture infectious dose 50 (T.C.I.D.50). The results demonstrated that M cells are also required in transfer of resistance to X-irradiated, bone marrow reconstituted mice and that spleen cells of 89Strontium-treated mice can inhibit their differentiation." @default.
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- W123766367 date "1982-01-01" @default.
- W123766367 modified "2023-10-16" @default.
- W123766367 title "NATURAL RESISTANCE AGAINST MOUSE HEPATITIS VIRUS 3" @default.
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- W123766367 doi "https://doi.org/10.1016/b978-0-12-341360-4.50218-3" @default.
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