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- W123896251 abstract "The need to replace animals in cutaneous pharmacotoxicology, together with the desire to develop biological systems to understand the underlying mechanisms, has led to the emergence of methods based mostly on cell culture or excised skin models. Thus, in future, some of the beneficial or detrimental properties of dermatological products would be deduced from their mechanisms of action and not from clinical effects observed in animals (or occasionally humans). Two types of skin cell culture are currently feasible: classical systems using conventional culture dishes as a support, and systems reconstructing the three-dimensional structure of the different skin compartments. In the case of the reconstructed epidermis (composed of keratinocytes and eventually melanocytes) or reconstructed skin (composed of keratinocytes and fibroblasts), an immersion step is required for epidermal differentiation. The main reactions involved in cutaneous toxicology are: non-immunological contact dermatitis (due to irritation) and immunological contact dermatitis (due to sensitization); pigment alteration; comedogenesis; and carcinogenesis. This chapter describes various in vitro models and tests available for cutaneous pharmacotoxicology, and their assessment." @default.
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- W123896251 date "1997-01-01" @default.
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- W123896251 title "Cutaneous Pharmacotoxicology In Vitro" @default.
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