Matches in SemOpenAlex for { <https://semopenalex.org/work/W1240007> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1240007 endingPage "23" @default.
- W1240007 startingPage "1519" @default.
- W1240007 abstract "The latex of 'Crown-of-Thorns' (Euphorbia milii var. hislopii, syn. E. splendens) has been shown to be a potent plant molluscicide that could be used against the snails which are intermediate hosts of Schistosoma trematodes. However, a comprehensive toxicological evaluation of the latex is necessary before its large-scale use in schistosomiasis control becomes possible. In fact, one cause for concern is the presence of tumor-promoting phorbol esters in several plants of the Euphorbiaceae family. Phorbol esters as well as a number of other known tumor promoters share the common property of inhibiting metabolic cooperation (i.e., exchange of low molecular weight molecules via gap junctions) between Chinese hamster V79 cells in monolayer cultures. The present study was undertaken to determine if latex of E. milii presents tumor promoter-like activity is this short-term in vitro assay. Samples of lyophilized E. milii latex were tested at a noncytotoxic concentration range (1, 10, 50 and 100 micrograms/ml) in three independent experiments. 12-O-Tetradecanoylphorbol-13-acetate (10 ng/ml) was used as positive control. In all three assays, E. milii latex consistently inhibited metabolic cooperation between V79 cells at concentrations > or = 10 micrograms/ml. These results that E. milii latex contains tumor-promoting substances. These findings suggest that the use of crude latex as a molluscicide may pose a carcinogenic hazard to people who are continuously exposed to the product." @default.
- W1240007 created "2016-06-24" @default.
- W1240007 creator A5026131093 @default.
- W1240007 creator A5028700263 @default.
- W1240007 creator A5050889155 @default.
- W1240007 creator A5072783768 @default.
- W1240007 creator A5084769142 @default.
- W1240007 date "1996-11-01" @default.
- W1240007 modified "2023-09-27" @default.
- W1240007 title "Tumor promoter-like activity of the molluscicidal latex of 'Crown-of-Thorns' (Euphorbia milii var. hislopii) in the V79 metabolic cooperation assay." @default.
- W1240007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9196556" @default.
- W1240007 hasPublicationYear "1996" @default.
- W1240007 type Work @default.
- W1240007 sameAs 1240007 @default.
- W1240007 citedByCount "2" @default.
- W1240007 countsByYear W12400072015 @default.
- W1240007 crossrefType "journal-article" @default.
- W1240007 hasAuthorship W1240007A5026131093 @default.
- W1240007 hasAuthorship W1240007A5028700263 @default.
- W1240007 hasAuthorship W1240007A5050889155 @default.
- W1240007 hasAuthorship W1240007A5072783768 @default.
- W1240007 hasAuthorship W1240007A5084769142 @default.
- W1240007 hasConcept C104488531 @default.
- W1240007 hasConcept C153911025 @default.
- W1240007 hasConcept C18903297 @default.
- W1240007 hasConcept C2777087035 @default.
- W1240007 hasConcept C2779047212 @default.
- W1240007 hasConcept C2779965526 @default.
- W1240007 hasConcept C33070731 @default.
- W1240007 hasConcept C54355233 @default.
- W1240007 hasConcept C55493867 @default.
- W1240007 hasConcept C556039675 @default.
- W1240007 hasConcept C59822182 @default.
- W1240007 hasConcept C71924100 @default.
- W1240007 hasConcept C86803240 @default.
- W1240007 hasConceptScore W1240007C104488531 @default.
- W1240007 hasConceptScore W1240007C153911025 @default.
- W1240007 hasConceptScore W1240007C18903297 @default.
- W1240007 hasConceptScore W1240007C2777087035 @default.
- W1240007 hasConceptScore W1240007C2779047212 @default.
- W1240007 hasConceptScore W1240007C2779965526 @default.
- W1240007 hasConceptScore W1240007C33070731 @default.
- W1240007 hasConceptScore W1240007C54355233 @default.
- W1240007 hasConceptScore W1240007C55493867 @default.
- W1240007 hasConceptScore W1240007C556039675 @default.
- W1240007 hasConceptScore W1240007C59822182 @default.
- W1240007 hasConceptScore W1240007C71924100 @default.
- W1240007 hasConceptScore W1240007C86803240 @default.
- W1240007 hasIssue "11" @default.
- W1240007 hasLocation W12400071 @default.
- W1240007 hasOpenAccess W1240007 @default.
- W1240007 hasPrimaryLocation W12400071 @default.
- W1240007 hasRelatedWork W1519384863 @default.
- W1240007 hasRelatedWork W1986038295 @default.
- W1240007 hasRelatedWork W2148431552 @default.
- W1240007 hasRelatedWork W2279203154 @default.
- W1240007 hasRelatedWork W2588733733 @default.
- W1240007 hasRelatedWork W2623085360 @default.
- W1240007 hasRelatedWork W2743136405 @default.
- W1240007 hasRelatedWork W2746551496 @default.
- W1240007 hasRelatedWork W43695720 @default.
- W1240007 hasRelatedWork W2481927599 @default.
- W1240007 hasVolume "29" @default.
- W1240007 isParatext "false" @default.
- W1240007 isRetracted "false" @default.
- W1240007 magId "1240007" @default.
- W1240007 workType "article" @default.