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• W1240035049 abstract "S-nitrosylation of mitochondrial enzymes involved in energy transfer under nitrosative stress may result in ATP deficiency. We investigated whether α-lipoic acid, a powerful antioxidant, could alleviate nitrosative stress by regulating S-nitrosylation, which could result in retaining the mitochondrial enzyme activity.In this study, we have identified the S-nitrosylated forms of subunit 1 of dihydrolipoyllysine succinyltransferase (complex III), and subunit 2 of the α-ketoglutarate dehydrogenase complex by implementing a fluorescence-based differential quantitative proteomics method.We found that the activities of these two mitochondrial enzymes were partially but reversibly inhibited by S-nitrosylation in cultured endothelial cells, and that their activities were partially restored by supplementation of α-lipoic acid. We show that protein S-nitrosylation affects the activity of mitochondrial enzymes that are central to energy supply, and that α-lipoic acid protects mitochondrial enzymes by altering S-nitrosylation levels.Inhibiting protein S-nitrosylation with α-lipoic acid seems to be a protective mechanism against nitrosative stress.Identification and characterization of these new protein targets should contribute to expanding the therapeutic power of α-lipoic acid and to a better understanding of the underlying antioxidant mechanisms." @default.
• W1240035049 created "2016-06-24" @default.
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• W1240035049 date "2016-01-01" @default.
• W1240035049 modified "2023-09-27" @default.
• W1240035049 title "Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress" @default.
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• W1240035049 doi "https://doi.org/10.1016/j.bbagen.2015.09.001" @default.
• W1240035049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5293714" @default.
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