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- W1241081 abstract "Anaemia in the cancer patient is widely recognised as an important factor in determining the outcome of various forms of treatment. Animal studies have shown in several tumour lines that acute reductions in haematocrit produce a significant increase in the hypoxic fraction of tumour cells, thus rendering the tumour cells more resistant to radiotherapy (Hirst et al., 1984; Siemann et al., 1975). Where inspired air of low oxygen content has been used to induce anaemia, the reduced radiosensitivity has been attributed to a reduction in O2 availability resulting from the low pO2 in the arterial blood, whilst induction by phlebotomy, with subsequent plasma replacement, directly reduces the Hb concentration of the blood, thus reducing the O2 carrying capacity. It may be expected that compensatory mechanisms act to increase the cardiac output to maintain the supply of oxygen to tissues. The way in which any such increase affects the relative distribution of blood between tumours and normal tissues has not been closely investigated as yet. This study examines how the cardiac output is distributed between 5 minutes and 6 hours after the onset of anaemia." @default.
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- W1241081 date "1994-01-01" @default.
- W1241081 modified "2023-09-24" @default.
- W1241081 title "Relative Perfusion of Tumours in Two Sites for up to 6 Hours after the Induction of Anaemia" @default.
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- W1241081 doi "https://doi.org/10.1007/978-1-4615-2468-7_49" @default.
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