Matches in SemOpenAlex for { <https://semopenalex.org/work/W1241489072> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1241489072 endingPage "152" @default.
- W1241489072 startingPage "147" @default.
- W1241489072 abstract "Background. The purpose of this study was to determine whether transient ischemic preconditioning protects human myocardium against normothermic ischemic injury.Methods. Isolated human right atrial trabeculae were suspended in an organ bath with oxygenated Tyrode’s solution at 37°C and field stimulated at 1 Hz. Developed force was recorded. Trabeculae (Warm I/R) received normoxic perfusion before 45 minutes of normothermic simulated ischemia (hypoxic, substrate-free buffer with pacing at 3 Hz) and 120 minutes of reperfusion. Preconditioned trabeculae (Warm IPC) were subjected to 5 minutes of normothermic simulated ischemia and 10 minutes of perfusion before normothermic simulated ischemia-reperfusion injury. Trabeculae (Cold I/R) were subjected to hypothermic (4°C) ischemia (hypoxic buffer) for 4 hours and 60 minutes of reperfusion (37°C). Preconditioned trabeculae (Cold IPC) were pretreated with 5 minutes of normothermic simulated ischemia before hypothermic ischemia and 60 minutes of reperfusion. At the end of reperfusion, trabeculae were frozen at −70°C and assayed for tissue creatine kinase activity.Results. At the end of reperfusion, warm preconditioned trabeculae (Warm IPC) recovered 51% ± 5% of baseline developed force, whereas warm I/R trabeculae recovered 24% ± 3% (p < 0.05). Tissue creatine kinase levels reflecting preserved tissue viability were sustained in Warm IPC trabeculae (1,183 ± 204 U/g), whereas nonpreconditioned control trabeculae (Warm I/R) exhibited lower levels of enzymatic activity (403 ± 32 U/g) (p < 0.05). In contrast, Cold IPC trabeculae recovered 47% ± 5% and Cold I/R, 56% ± 8% of baseline developed force at the end of reperfusion (p > 0.05).Conclusions. We conclude that transient ischemic preconditioning protects human myocardium against normothermic ischemic injury.(Ann Thorac Surg 1997;63:147–52)" @default.
- W1241489072 created "2016-06-24" @default.
- W1241489072 creator A5004545352 @default.
- W1241489072 creator A5013438877 @default.
- W1241489072 creator A5024786878 @default.
- W1241489072 creator A5051911084 @default.
- W1241489072 creator A5087253902 @default.
- W1241489072 date "1997-01-01" @default.
- W1241489072 modified "2023-10-16" @default.
- W1241489072 title "Preconditioning and Hypothermic Cardioplegia Protect Human Heart Equally Against Ischemia" @default.
- W1241489072 cites W1971510227 @default.
- W1241489072 cites W1973373753 @default.
- W1241489072 cites W1975181581 @default.
- W1241489072 cites W1987664769 @default.
- W1241489072 cites W2002179621 @default.
- W1241489072 cites W2026153674 @default.
- W1241489072 cites W2026826353 @default.
- W1241489072 cites W2039559715 @default.
- W1241489072 cites W2051035231 @default.
- W1241489072 cites W2063448257 @default.
- W1241489072 cites W2074124391 @default.
- W1241489072 cites W2078416377 @default.
- W1241489072 cites W2083275191 @default.
- W1241489072 cites W2093182615 @default.
- W1241489072 cites W2094959922 @default.
- W1241489072 cites W2129167542 @default.
- W1241489072 cites W2146217294 @default.
- W1241489072 cites W224801659 @default.
- W1241489072 doi "https://doi.org/10.1016/s0003-4975(96)00924-1" @default.
- W1241489072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8993257" @default.
- W1241489072 hasPublicationYear "1997" @default.
- W1241489072 type Work @default.
- W1241489072 sameAs 1241489072 @default.
- W1241489072 citedByCount "36" @default.
- W1241489072 countsByYear W12414890722014 @default.
- W1241489072 countsByYear W12414890722022 @default.
- W1241489072 crossrefType "journal-article" @default.
- W1241489072 hasAuthorship W1241489072A5004545352 @default.
- W1241489072 hasAuthorship W1241489072A5013438877 @default.
- W1241489072 hasAuthorship W1241489072A5024786878 @default.
- W1241489072 hasAuthorship W1241489072A5051911084 @default.
- W1241489072 hasAuthorship W1241489072A5087253902 @default.
- W1241489072 hasBestOaLocation W12414890721 @default.
- W1241489072 hasConcept C126322002 @default.
- W1241489072 hasConcept C146957229 @default.
- W1241489072 hasConcept C164705383 @default.
- W1241489072 hasConcept C2777390192 @default.
- W1241489072 hasConcept C2780114680 @default.
- W1241489072 hasConcept C36880943 @default.
- W1241489072 hasConcept C42219234 @default.
- W1241489072 hasConcept C541997718 @default.
- W1241489072 hasConcept C71924100 @default.
- W1241489072 hasConceptScore W1241489072C126322002 @default.
- W1241489072 hasConceptScore W1241489072C146957229 @default.
- W1241489072 hasConceptScore W1241489072C164705383 @default.
- W1241489072 hasConceptScore W1241489072C2777390192 @default.
- W1241489072 hasConceptScore W1241489072C2780114680 @default.
- W1241489072 hasConceptScore W1241489072C36880943 @default.
- W1241489072 hasConceptScore W1241489072C42219234 @default.
- W1241489072 hasConceptScore W1241489072C541997718 @default.
- W1241489072 hasConceptScore W1241489072C71924100 @default.
- W1241489072 hasIssue "1" @default.
- W1241489072 hasLocation W12414890721 @default.
- W1241489072 hasLocation W12414890722 @default.
- W1241489072 hasOpenAccess W1241489072 @default.
- W1241489072 hasPrimaryLocation W12414890721 @default.
- W1241489072 hasRelatedWork W2006800517 @default.
- W1241489072 hasRelatedWork W2009318994 @default.
- W1241489072 hasRelatedWork W2120430088 @default.
- W1241489072 hasRelatedWork W2139030481 @default.
- W1241489072 hasRelatedWork W2154227981 @default.
- W1241489072 hasRelatedWork W2365513230 @default.
- W1241489072 hasRelatedWork W2365761185 @default.
- W1241489072 hasRelatedWork W2407490093 @default.
- W1241489072 hasRelatedWork W2741562667 @default.
- W1241489072 hasRelatedWork W3147238946 @default.
- W1241489072 hasVolume "63" @default.
- W1241489072 isParatext "false" @default.
- W1241489072 isRetracted "false" @default.
- W1241489072 magId "1241489072" @default.
- W1241489072 workType "article" @default.