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- W124153945 abstract "732 Objectives: To study the effect of actin depolymerizing factor (ADF)/cofilin on repression of xenograft human lung tumor growth by luciferase reporter gene based optical imaging. Methods: A human non-small lung cancer H1299 cell line was stabily transfected with a tet-on gene inducible system and a bidirectional reporter gene system that can co-express cofilin gene and luciferase reporter gene. After cells were s.c. implanted into NOD-SCID mouse, the inducer doxycycline was administrated to induce the gene expression in vivo. The change of tumorigenesis was tracked by IVIS 50 Bioluminescnece Imaging system. Results: The xenograft lung tumor in mice fed with doxycycline was able to exhibit significant luciferase activity by optical imaging as compared to the controls. However, the bioluminescent signals were gradually reduced, and completely diminished after 5 weeks. The tumor never grew, wherease the xenograft tumors were normally proliferated in the mice fed without doxycycline. Conclusions: It appears that cofilin can repress tumorigenesis after over-expression. The optical imaging is successfully noninvasively real-time detect the therapeutic effect of cofilin. Research Support: National Science Council grant (NSC96-2321-B-010-006-MY3)" @default.
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- W124153945 date "2008-05-01" @default.
- W124153945 modified "2023-09-26" @default.
- W124153945 title "Imaging of actin depolymerizing factor (ADF)/cofilin over-expression on tumor control by bioluminescence" @default.
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