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- W124199649 abstract "Stem and progenitor cells promote repair of injured tissues by contributing to new blood vessel, muscle, and nerve formation. These same cells may contribute to tumor growth and spread by promoting new blood vessel growth and stimulating tumor invasiveness. Tumors can express factors that simultaneously induce both angiogenesis and neurogenesis, such as guidance receptors and ligands that regulate branching morphogenesis in neuronal and vascular systems. Vascular endothelial growth factor, brain-derived neurotrophic factor, Neuropilins, Semaphorins, Netrins, and Slit/Robos can promote branching morphogenesis of both neurons and blood vessels. Some of these factors can stimulate stem or progenitor cells to promote tumor angiogenesis and neurogenesis as well as tumor growth and spread. Innervation of tumors promotes cancer pain and can contribute to tumor spread along axons. An understanding of the mechanisms promoting development of neurons and blood vessels during tumor progression will assist in the development of new cancer therapies." @default.
- W124199649 created "2016-06-24" @default.
- W124199649 creator A5056635548 @default.
- W124199649 date "2009-01-01" @default.
- W124199649 modified "2023-10-17" @default.
- W124199649 title "Stem Cells, Angiogenesis, and Neurogenesis in Tumors" @default.
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- W124199649 doi "https://doi.org/10.1007/978-1-60327-933-8_19" @default.
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